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Molecular genetics and related developments in pancreatic cancer.

Hruban(R H),Goggins(M),Kern(S E) Curr Opin Gastroenterol 2007-07-03

...BRCA2 (7%) tumor suppressor genes. An understanding of the molecular genetics of carcinoma of the pancreas is important ...

Contribution of BRCA1 and BRCA2 germline mutations to the incidence of early-on…

Loizidou(M),Marcou(Y),Anastasiadou(V),Newbol… Clin Genet 2007-04-11

...BRCA2 [c.3531-3534delCAGC (3758del4), c.8755delG (8984delG)] in six of 26 unrelated patients. The BRCA2 mutation c.3531-...

Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repair.

Zhou(Qingwen),Kojic(Milorad),Cao(Zhimin),Lis… Mol Cell Biol 2007-04-30

...BRCA2 ortholog in Ustilago maydis, enables recombinational repair of DNA by controlling Rad51 and is in turn regulated b...

MRI in the early detection of breast cancer in women with high genetic risk.

Trecate(Giovanna),Vergnaghi(Daniele),Manouki… Tumori 2007-02-20

Women with BRCA1 or BRCA2 germline mutations have an elevated risk of developing breast and/or ovarian cancer. Because o...

Male breast cancer: a review of clinical management.

Agrawal(A),Ayantunde(A A),Rampaul(R),Roberts… Breast Cancer Res Treat 2007-09-19

...BRCA2 families; testicular dysfunction due to chromosomal abnormality such as Klinefelter's syndrome or environmental fa...

Inhibition of homologous recombination repair in irradiated tumor cells pretrea…

Noguchi(Miho),Yu(Dong),Hirayama(Ryoichi),Nin… Biochem Biophys Res Commun 2007-01-09

...BRCA2 was a novel client protein for Hsp90, and 17-AAG caused the degradation of BRCA2 and in turn altered the behavior ...

Cellular functions of the BRCA tumour-suppressor proteins.

Boulton(S J) Biochem Soc Trans 2007-01-29

Inherited germline mutations in either BRCA1 or BRCA2 confer a significant lifetime risk of developing breast or ovarian...

The role of hereditary nonpolyposis colorectal cancer in the management of fami…

Farrell(Carolyn),Lyman(Mollie),Freitag(Kathe… Genet Med 2007-01-09

...BRCA2 genes. Hereditary nonpolyposis colorectal cancer, another common syndrome, is also associated with ovarian cancer ...

MDM2 SNP309 accelerates familial breast carcinogenesis independently of estroge…

Wasielewski(Marijke),Nagel(Jord H A),Brekelm… Breast Cancer Res Treat 2007-11-27

...BRCA2. Cancer acceleration was indeed observed in early-onset familial breast cancer cases (diagnosed

High proportion of BRCA1/2 founder mutations in Hispanic breast/ovarian cancer …

Torres(Diana),Rashid(Muhammad Usman),Gil(Fab… Breast Cancer Res Treat 2007-08-02

...BRCA2 mutation for 40% of all BRCA2 mutations. Haplotype analyses suggested that each of these mutations has arisen from...

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