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Shimokawa(K),Ono(K),Asano(M),Hirayama(T),T... ACS Med Chem Lett 2026-07-09

...BRCA2, which are essential in maintaining genomic stability. In this study, we describe the lead optimization of a 1,4-t...

Fu(F),Chu(F),Wan(Q),Zhang(Y),Xie(Y) Gland Surg 2026-06-30

...BRCA2 carriers) underwent NSM and immediate breast reconstruction at Peking University International Hospital from Janua...

Sun(X),Zhu(R),Feng(Q),Li(P),Zhang(Y),Xia(Q... Med Chem Res 2026-05-00

...brca2 genes to improve vascular endothelial cell proliferation and migration in zebrafish. In summary, our findings sugg...

de Souza(DC),Buranello(T),Neto(DTT),Pisani... Gastric Cancer 2026-09-00

...BRCA2 gene was the most frequently mutated (n = 3, 27.3%). Whole exome sequencing showed candidate genes, such as FBXO24...

Morimoto(Y),Musha(Y),Takeuchi(O),Inano(H),... Discov Oncol 2026-07-14

...BRCA2-deficient Capan-1 cells. Compared with monotherapy, combination therapy markedly enhanced apoptosis and suppressed...

Kaulfuss(JC),Jeutner(J),Erber(B),Siech(C),... Cancers (Basel) 2026-06-23

...BRCA2 were recognized by 96.6% of respondents. Knowledge of other PC-associated genes was much lower. Conclusions: Despi...

Mikheeva(R),Leonov(P),Koryukov(M),Ruleva(E... Int J Mol Sci 2026-06-26

...BRCA2. However, its landscape of large genomic rearrangements (LGRs) and copy number variants (CNVs) is still far from b...

Urbut(SM),Ding(Y),Nakao(T),Koyama(S),Misra... Nature 2026-08-00

...BRCA2 (refs. 7,8) aligns with disease specificities. A signature-based genome-wide association study identifies 151 geno...

Cipri(S),Agolini(E),Baldo(GD),Cacchione(A)... ESMO Open 2026-08-00

...BRCA2 DNA repair associated (BRCA2), two key DNA repair genes, are strongly linked to adult-onset malignancies and play ...

Nguyen(HT),Vu(MD),Nguyen(DD),Dinh(PN),Hoan... BMC Cancer 2026-07-17

...BRCA2 (40/57 BRCA1 vs 17/57 BRCA2 in ovarian cancer and 57/78 BRCA1 vs 21/78 BRCA2 in TNBC). Several BRCA1 truncating va...