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Histopathological features of breast tumours in BRCA1, BRCA2 and mutation-negat…

Eerola(Hannaleena),Heikkilä(Päivi),Tamminen(… Breast Cancer Res 2006-01-31

Histopathological features of BRCA1 and BRCA2 tumours have previously been characterised and compared with unselected br...

Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 m…

Lovelock(P K),Healey(S),Au(W),Sum(E Y M),Tes… J Med Genet 2006-12-15

...BRCA2.

Common variation in EMSY and risk of breast and ovarian cancer: a case-control …

Benusiglio(Patrick R),Lesueur(Fabienne),Lucc… BMC Cancer 2006-02-27

...BRCA2 exon 3.,We used a genetic association study design to determine if common genetic variation (frequency > or = 5%) ...

Hypoxia down-regulates DNA double strand break repair gene expression in prosta…

Meng(Alice X),Jalali(Farid),Cuddihy(Andrew),… Radiother Oncol 2006-01-24

...BRCA2) in both normal and malignant cultures. Similar decreases in RNA pertaining to the NHEJ-related genes (e.g. Ku70, ...

Comprehensive statistical study of 452 BRCA1 missense substitutions with classi…

Tavtigian(S V),Deffenbaugh(A M),Yin(L),Judki… J Med Genet 2006-06-16

...BRCA2 testing for hereditary breast and ovarian cancer is one such widely used test. However, clinical testing methods w...

Targeting the DNA repair defect of BRCA tumours.

Turner(Nicholas),Tutt(Andrew),Ashworth(Alan) Curr Opin Pharmacol 2006-05-24

...BRCA2 function. Both BRCA1 and BRCA2 proteins have been implicated in the repair of double-strand DNA breaks by homologo...

Screening for RAD51 and BRCA2 BRC repeat mutations in breast and ovarian cancer…

Rapakko(Katrin),Heikkinen(Katri),Karppinen(S… Cancer Lett 2006-06-28

...BRCA2 is of great importance, and the conserved BRC repeat motifs in BRCA2 are crucial for this interaction. In the curr...

Dissecting systems-wide data using mixture models: application to identify affe…

Svensson(J Peter),de Menezes(Renée X),Turess… BMC Bioinformatics 2006-03-22

...BRCA2 mutations.,We present an objective and unsupervised way to set thresholds adapted to the quality and design of the...

Hemochromatosis gene mutations among Finnish male breast and prostate cancer pa…

Syrjäkoski(Kirsi),Fredriksson(Henna),Ikonen(… Int J Cancer 2006-01-11

...BRCA2 mutation 9346(-2)A-->G compared with the rest of the MBC cases, indicating that HFE may be an MBC risk modifier ge...

Insertion/deletion polymorphism in the BRCA2 nuclear localization signal.

Yoshikawa(Yasunaga),Morimatsu(Masami),Ochiai… Biomed Res 2006-05-17

Mutations in human BRCA2 confer an increased risk of female breast cancer. In this study, we found a novel insertion/del...

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