BRCA1 and BRCA2 mutations significantly increase a women's lifetime risk of breast and ovarian cancer. Because several m...
...BRCA2 in the well-characterized BRCA2-deficient human cell line CAPAN-1 containing, as homologous recombination substrat...
Marked variation in phenotypic expression among BRCA1 and BRCA2 mutation carriers may be partly explained by modifier ge...
...BRCA2 Jewish founder mutations.,Patients with borderline tumors were younger at diagnosis, and more frequently of the se...
...BRCA2. The significance of homologous recombination for the cell is underscored by the evolutionary conservation of the ...
...BRCA2, or TP53 mutation. We recruited participants from 22 centres in the UK, and offered the women annual screening wit...
Individuals carrying germline mutations in one allele of the BRCA1 or BRCA2 genes are at significantly increased risk of...
...BRCA2. In sporadic breast cancer, however, there is evidence for the involvement of a different pathway of DNA repair, n...
...BRCA2 mutations. We offered genetic counseling and DNA analysis to selected patients. About 52% of patients showed at le...
...BRCA2, to a multicapillary DNA sequencer in order to increase the throughput of this technique. This new method that we ...
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