文献库搜索 | GeneLibs

McNevin(CS),Murphy(K),Murchan(P),Hennessy(... Eur J Hum Genet 2026-09-03

Poly(ADP-ribose) polymerase inhibitors (PARPi) have revolutionized the management of BRCA1- and BRCA2-associated ovarian...

Milambo(JPM),Chitha(WW) Asian Pac J Cancer Prev 2026-08-01

BRCA1 and BRCA2 gene mutations are major contributors to hereditary breast and ovarian cancer syndrome (HBOC). While mut...

Sukpan(P),Khongcharoen(N),Samphao(S) Asian Pac J Cancer Prev 2026-08-01

...BRCA2 genes. This study represents the first and largest investigation of germline CNVs in the BRCA1 and BRCA2 genes wit...

Ferrandi(G),Bagnolini(G),Poppi(L),Masi(M),... ACS Med Chem Lett 2026-02-12

...BRCA2 and PARP as a synthetic lethal target pair to consolidate the use of small molecule inhibitors of RAD51-BRCA2 prot...

Germain(LS),Ott(BP),Hindmarch(CCT),Winn(LM... Environ Epigenet None

...brca2 gene, a key DNA damage enzyme. Integration of RNA-seq and WGBS datasets identified nine genes with both expression...

Zabarsky-Shasha(G),Raitses-Gurevich(M),Sto... Hum Pathol 2026-06-17

Pancreatic ductal adenocarcinoma arising in carriers of germline BRCA1 or BRCA2 mutations represents a molecularly defin...

Huang(Z),Abbas(M),Hussain(A),Long(M),Muzam... Front Cell Dev Biol None

...BRCA2-mediated azoospermia), while fostering genomic instability that drives carcinogenesis. Clinically, distinct phenot...

Maiorano(MFP),Cormio(G),De Serio(I),Torzil... Gynecol Oncol 2026-08-00

...BRCA2 carriers (p = 0.119). Specific BRCA mutation was available for 154/291 patients (52.9%); BRCA1 c.5266dupC was the ...

El Makhzen(N),El Hejjioui(B),ElMakhzen(B),... J Mol Diagn 2026-09-00

Accurate detection of BRCA1 and BRCA2 variants is essential for breast cancer diagnosis. However, the large size of thes...

Özdemir-Pehlivan(Z),Büke(A),Çevik-Demir(E)... Mutat Res 2026-06-19

...BRCA2, yet clinical interpretation of intermediate-penetrance genes remains challenging. We retrospectively evaluated un...