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Understanding breast cancer risk -- where do we stand in 2005?

Dumitrescu(R G),Cotarla(I) J Cell Mol Med 2005-04-21

...BRCA2, p53, PTEN, ATM, NBS1 or LKB1) and low-penetrance genes such as cytochrome P450 genes (CYP1A1, CYP2D6, CYP19), glu...

Reproductive issues for women with BRCA mutations.

Friedman(Lois C),Kramer(Rita M) J Natl Cancer Inst Monogr 2005-06-21

...BRCA2 mutations face difficult and confusing reproductive decisions that fall into three categories: issues relating to ...

Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fan…

Houghtaling(Scott),Granville(Laura),Akkari(Y… Cancer Res 2005-03-02

...BRCA2) and D2. We have previously reported an increased incidence of epithelial tumors in Fancd2 knockout mice. To furth...

Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cance…

Jekimovs(C R),Chen(X),Arnold(J),Gatei(M),Ric… Br J Cancer 2005-03-24

...BRCA2. Only two (0.6%) index cases heterozygous for the CHEK2 mutation were identified. All available relatives in these...

Nuclear localization of Rad51B is independent of Rad51C and BRCA2.

Miller(Kristi A),Hinz(John M),Yamada(N Alice… Mutagenesis 2005-06-09

...BRCA2 mutant cell line, CAPAN-1, showed that Rad51B also localizes to the nucleus independent of BRCA2. Although both Ra...

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA ju…

Yang(Haijuan),Li(Qiubai),Fan(Jie),Holloman(W… Nature 2005-03-03

...BRCA2 in repair has been unclear. Here we show that a full-length BRCA2 homologue (Brh2) stimulates Rad51-mediated recom...

Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobu…

Hatanaka(Atsushi),Yamazoe(Mitsuyoshi),Sale(J… Mol Cell Biol 2005-03-09

BRCA2 is a tumor suppressor gene that is linked to hereditary breast and ovarian cancer. Although the Brca2 protein part...

Additional salpingectomy after previous prophylactic oophorectomy in high-risk …

Olivier(Roelien I),Lubsen-Brandsma(Lottie A … Gynecol Oncol 2005-03-03

...BRCA2 carrier, one BRCA1 and 2 carrier, and three women with non-informative test results. The procedure was readily don...

A population-based assessment of the clustering of breast cancer in families el…

Lorenzo Bermejo(J),Hemminki(K) Ann Oncol 2005-07-12

...BRCA2 mutations. Non-BRCA1/2 related effects are probably involved in the strong clustering of breast cancer in families...

Epidemiology of male breast cancer.

Weiss(Joli R),Moysich(Kirsten B),Swede(Helen) Cancer Epidemiol Biomarkers P… 2005-04-20

...BRCA2 mutations, which are believed to account for the majority of inherited breast cancer in men, Klinefelter syndrome,...

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