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Perspectives in the clinical management of BRCA mutations carriers.

Savarese(A),Cognetti(F) J Exp Clin Cancer Res 2003-07-31

...BRCA2 is changing the clinical care provided to women at high-risk of breast cancer. We briefly review what is currently...

The Italian multi-centre project on evaluation of MRI and other imaging modal...

Podo(F),Sardanelli(F),Canese(R),D'Agnolo(G... J Exp Clin Cancer Res 2003-07-31

...BRCA2 mutation carriers or had a 1 in 2 probability of being carriers (40/105 with a previous personal history of BC). E...

Mutation analysis of BrCA1, BrCA2, and p53 versus soluble HLA class I and cla...

Goumenou(Anastasia G),Vassiliadis(Simon),M... Fertil Steril 2003-04-03

To investigate possible correlation(s) between mutations of BrCA1, BrCA2, and p53 genes versus soluble HLA expression in...

Clinical considerations in the management of individuals at risk for heredita...

Robson(Mark E) Cancer Control 2003-03-26

Hereditary predisposition to breast and ovarian cancer, most commonly due to germline mutations in BRCA1 and BRCA2, has ...

p53 mediates repression of the BRCA2 promoter and down-regulation of BRCA2 mR...

Wu(Kangjian),Jiang(Shi-Wen),Couch(Fergus J... J Biol Chem 2003-06-17

...BRCA2 mRNA and protein levels by altering both BRCA2 mRNA stability and protein stability. Thus, BRCA2 levels in the cel...

Prophylactic surgery and other strategies for reducing the risk of familial o...

Swisher(Elizabeth) Curr Treat Options Oncol 2003-07-07

...BRCA2 mutations are diagnosed with occult cancer at the time of surgical prophylaxis. Surgical prophylaxis should includ...

BRCA1 and BRCA2 mutation status and tumor characteristics in male breast canc...

Ottini(Laura),Masala(Giovanna),D'Amico(Cri... Cancer Res 2003-03-13

...BRCA2, including mutations recurring in Central Italy (BRCA1 3345delAG and BRCA2 6696delTC). The a priori probability of...

BRCA1/2 mutation status influences somatic genetic progression in inherited a...

Ramus(Susan J),Pharoah(Paul D P),Harringto... Cancer Res 2003-03-13

...BRCA2 mutation carriers, individuals with familial non-BRCA1/2 epithelial ovarian cancer, and women with nonfamilial epi...

BRCA2 germline mutations in familial pancreatic carcinoma.

Hahn(Stephan A),Greenhalf(Bill),Ellis(Ian)... J Natl Cancer Inst 2003-02-20

...BRCA2 gene that are predicted to result in a truncated BRCA2 protein. Two additional families harbored mutations previou...

A high-throughput nonisotopic protein truncation test.

Gite(Sadanand),Lim(Mark),Carlson(Rick),Ole... Nat Biotechnol 2003-09-16

...BRCA2 (breast and ovarian cancer), PKD1 (polycystic kidney disease), NF1 and NF2 (neurofibromatosis), and DMD (Duchenne ...

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