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Matos(AC),Lima(M),Miranda-Gonçalves(V),Ind... Cancer Lett 2026-02-28

...BRCA2, ATM, and PARP1, on RT response, highlighting their potential as therapeutic targets to overcome RR. We further ex...

Lynce(F),Graham(N),Kochupurakkal(BS),Nguye... Clin Cancer Res 2026-02-04

...BRCA2) were enrolled. The RP2D was not determined due to hematologic toxicities. The objective response rate (ORR) was 5...

Yamada(A),Oshi(M),Isa(T),Koyasu(T),Takatsu... Jpn J Clin Oncol 2026-03-13

...BRCA2 (31 individuals). The most common cancer was breast cancer (74.6%), followed by ovarian (13.6%), and pancreatic ca...

Ikegami(M),Zhang(L),Hirata(M),Yamaguchi(T)... Clin Cancer Res 2026-02-17

...BRCA2 (13%-16% in ovarian/peritoneal cancers), and NF1 (16% in peripheral nerve tumors). Genes with >50% GCR included RA...

Rugo(HS),Cescon(DW),Robson(ME),Im(SA),Dale... Clin Cancer Res 2026-03-02

...BRCA2 mutations (tBRCAm), HRs for PFS (HR, 0.70; 95% CI, 0.33-1.48) and OS (0.81; 95% CI, 0.28-2.37) favored pembrolizum...

Chang(TY),Chien(YW),Chen(SH),Sokolow(A),Wa... Cancer Res 2026-04-02

...BRCA2), leading to a double "two-hit" involving TP53 and BRCA1/2. Tumor invasion was associated with the activation of i...

Moghadasi(S),Zanti(M),Bleeker(F),Blok(M),B... J Med Genet 2026-02-20

The BRCA2 c.8351G>A p.(Arg2784Gln) variant has long been classified as a variant of uncertain significance (VUS) due to ...

Ferla(S),Fucina(S),Clemente(N),Spessotto(P... Ann Surg Oncol 2026-04-00

...BRCA2 mutation underwent laparoscopic bilateral adnexectomy as a prophylactic procedure. The real-time microscopic image...

Jurgiel(WA),Panasiuk(B),Posmyk(R) Discov Oncol 2026-01-15

...BRCA2 underlie the majority of hereditary ovarian cancers and belong to the group of genes with high penetrance which me...

Mishra(AP),Sahu(S),Sengodan(S),Moore(G),Pr... bioRxiv 2026-01-08

...BRCA2 function and mediate RAD51 loading during homologous recombination (HR). Their number varies across species, but m...