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A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair an...

Rafii(Saeed),O'Regan(Paul),Xinarianos(Geor... Hum Mol Genet 2002-08-30

...BRCA2 in the homologous recombination repair (HRR) of double-strand breaks in DNA implicates this pathway in the suppres...

Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation.

Kauff(Noah D),Satagopan(Jaya M),Robson(Mar... N Engl J Med 2002-05-28

...BRCA2 mutations identified during a six-year period were offered enrollment in a prospective follow-up study. A total of...

Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations.

Rebbeck(Timothy R),Lynch(Henry T),Neuhause... N Engl J Med 2002-05-28

...BRCA2 mutations are limited. We investigated whether this procedure reduces the risk of cancers of the coelomic epitheli...

The contribution of inherited factors to the clinicopathological features and...

Foulkes(W D),Rosenblatt(J),Chappuis(P O) J Mammary Gland Biol Neoplasia 2002-06-17

...BRCA2, which from a population perspective are much more important than TP53. Other rarer genes have subsequently been i...

BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and preval...

Berry(Donald A),Iversen(Edwin S),Gudbjarts... J Clin Oncol 2002-06-20

...BRCA2. Genetic testing for BRCA1 and BRCA2 is highly sensitive, missing an estimated 15% of mutations. In the population...

Pathologic findings in prophylactic oophorectomy specimens in high-risk women...

Leeper(Katherine),Garcia(Rochelle),Swisher... Gynecol Oncol 2002-12-16

...BRCA2 genes or had family history suggestive for ovarian and breast cancer susceptibility.,Thirty women with either a do...

Clustering of individuals with both breast and ovarian cancer--a possible ind...

Einbeigi(Zakaria),Meis-Kindblom(Jeanne M),... Acta Oncol 2002-07-29

...BRCA2 gene mutations. These results suggest that genetic factors account for the excess in ovarian cancer that occurs in...

BRCA1 and BRCA2 mutations in Turkish familial and non-familial ovarian cancer...

Yazici(Hulya),Glendon(Gordon),Yazici(Hilal... Hum Mutat 2002-08-05

...BRCA2 mutations, six in BRCA1, and seven in BRCA2. We have further studied the non-familial ovarian cancer cases to dete...

Familial ovarian cancer.

Volm(Tanja) Curr Womens Health Rep 2002-07-26

...BRCA2 genes are at increased risk for the development not only of breast, but of ovarian cancer. The estimated lifetime ...

Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated ...

Wang(Chiang),McCarty(Ida M),Balazs(Louisa)... Biochem Biophys Res Commun 2002-08-09

...BRCA2, predisposes humans to breast and ovarian cancers. Inherited mutations in the BRCA2 gene are also known to cause s...

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