...BRCA2 mutations confirmed a significantly elevated frequency of 1100delC (28/507 [5.5%]; OR 4.2; 95% CI 2.4-7.2; P=.0002...
...BRCA2, coupled with the activation of oncogenes such as K-ras, are a few of the mutations that trigger the growth of can...
...BRCA2 mutant breast tumors, 15 breast tumors from high-risk patients with no BRCA1 or BRCA2 mutations, and 62 matched sp...
...BRCA2-like," suggesting that BRCA1-related and BRCA2-related pathways are also involved in sporadic ovarian cancers. Fif...
...BRCA2 mutations and identify germ-line BRCA2 mutations as the most common inherited genetic alteration yet identified in...
...BRCA2 carriers and noncarriers among the women with invasive ovarian cancer (median survival, 53.4 months v. 37.8 months...
...BRCA2 genetic testing, little is known about the psychologic impact of such testing in the clinical setting. The objecti...
Individuals carrying BRCA mutations are predisposed to breast cancer. The BRCA1 and BRCA2 proteins are required for homo...
...BRCA2. Allowing for a mutation detection sensitivity frequency of 70%, the carrier frequency for BRCA2 mutations was 8% ...
...BRCA2 genes. The method has the sensitivity to detect K-ras mutations diluted 1 : 20 with wild-type DNA, a p53 mutation ...
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