...BRCA2 PV carriers, and possibly pancreatic cancer for BRCA1 PV carriers, there is no evidence that BRCA1 and BRCA2 PV ca...
...BRCA2, RAD51) and the acceleration of RAD51 foci formation. Critically, these DNA repair-enhancing effects were abolishe...
...BRCA2 gene mutation was identified. The patient continued treatment with drugs except oxaliplatin. Lung metastasis appea...
...BRCA2 function represent a major mechanism of resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) in BRCA2-muta...
...BRCA2: 18%) and 17.5% had moderate penetrance PVs; Rate of disclosure of PV to at least one family member; receipt of fa...
...BRCA2, KRAS, and BRAF. Additional therapeutic targets were identified across diverse biomarkers. HRD was present in 53.2...
...BRCA2 mutations were associated with alveolar/stress/inflammatory responses and enhanced MHC-II antigen presentation, li...
...BRCA2 (8.14% vs. 3.16% in <40 y; median diagnosis 43 vs. 45 years). Age remained independently associated with P/LP dete...
...BRCA2, CHEK2, ATM, and CDK12. Results: HRR gene pathogenic or likely pathogenic alterations were identified in 18% (CI 9...
...BRCA2 (PALB2), as well as broader genomic scar signatures. Transcriptomic subtype and GATA-binding protein 6 (GATA6) exp...
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