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Real-world clinical outcomes, genetic testing patterns, and treatment pattern...

George(DJ),Kariburyo-Yay(F),Aggarwal(H),Te... Urol Oncol 2026-09-00

...BRCA2, BRIP1, CDK12, CHEK1, CHEK2, FANCL, PALB2, RAD51B, RAD51C, RAD51D, and RAD54L. Biomarker testing patterns and trea...

Large-scale Genomic Landscape and Clinical Outcomes of De Novo and Treatment-...

Iida(K),Tashiro(K),Urabe(F),Matsui(Y),Urab... Eur Urol Open Sci 2026-08-00

...BRCA2 (15% and 23%), and MYC (17% and 14%), with no statistically significant differences across histology and specimen ...

Examining the connection between BRCA1/2 mutations and uterine cancer: a comp...

Saleem(SM),Nasir(SAS),Nida(F),Khalid(M),Ga... Ann Med Surg (Lond) 2026-07-00

DNA fix needs BRCA1 and BRCA2. These genes stop bad cell growth. They sit on links 17 and 13. Bad changes in some genes ...

Uptake of risk-reducing medical interventions among female BRCA1/2 pathogenic...

Lloyd-Ellis(S),Kaur(P),Kwon(JS),Dawson(L),... Gynecol Oncol 2026-07-00

...BRCA2 pathogenic variant (PV) elevates risks of developing breast and ovarian cancer, and guidelines recommend preventiv...

HOXB13, a high-risk prostate cancer gene, also confers risk for breast cancer...

Ozen(F),Yegin(Z),Sayit(D) J Hum Genet 2026-09-00

...BRCA2, are primarily responsible for inherited breast cancers, while mutations in moderate-risk genes also increase susc...

Semantic embedding of variant effect annotations enables rapid and accurate p...

Wu(J),Stutzman(M),Muriello(M),Lincoln(J),B... Sci Rep 2026-05-23

...BRCA2, FBN1, ATM, PALB2, MYH7, USH2A, and PAH), achieving Leave-One-Out Cross-Validation (LOO-CV) MCC of 0.895-0.989 and...

Integrating enriched case data from national laboratory testing with populati...

Allen(S),Rowlands(CF),Garrett(A),Couch(F),... medRxiv 2026-05-17

...BRCA2, PALB2, ATM, CHEK2). A combined LLR was produced for 4,690 missense variants; 927 variants received evidence towar...

Adjuvant olaparib real world data for BRCA positive, HER2-negative high-risk ...

Finch(M),Booth(C),Frank(S),Patel(A),Sagoo(... J Oncol Pharm Pract 2026-05-25

...BRCA2 mutations, higher rates of hormone receptor positive HER2-negative cancers and a greater use of neoadjuvant and pl...

Gallbladder cancer with dual genetic variants of PMS2 and BRCA2: a case repor...

Sumii(R),Omote(S),Omote(R),Fujita(I),Toyok... Clin J Gastroenterol 2026-08-00

...BRCA2 and PMS2, alongside a high tumor mutational burden (18.2 mutations/Mb). The elevated tumor mutational burden and t...

Whole genome sequencing in oesophageal adenocarcinoma unmasks potential preci...

Sharma(S),Wong(HY),Johnston(RL),Koufarioti... BMC Cancer 2026-05-25

...BRCA2, CCNE1, CDKN2A, EGFR, KRAS, MDM2, PIK3CA, PTEN, SMARCB1 and TSC2. Candidate co-occurring alterations included co-o...

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