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BRCA1 and BRCA2 mutations in breast cancer families with multiple primary can...

Shih(H A),Nathanson(K L),Seal(S),Collins(N... Clin Cancer Res 2001-05-31

...BRCA2 (P < 0.001). BRCA1 and BRCA2 mutations were twice as common in the presence of a reported second nonovarian cancer...

Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded b...

Wang(H),Zeng(Z C),Bui(T A),DiBiase(S J),Qi... Cancer Res 2001-02-01

...BRCA2 genes predispose to a wide spectrum of familial cancers. The functions of the proteins encoded by BRCA1 and BRCA2 ...

Epithelial ovarian cancer: prevention, diagnosis, and treatment.

Partridge(E E),Barnes(M N) CA Cancer J Clin 2001-02-08

...BRCA2 genes--in at least 5% to 10% of all epithelial ovarian cancers. Oral contraceptives are known to reduce the risk f...

Screening for ovarian cancer: what we know, what we need to know.

Hensley(M L),Castiel(M),Robson(M E) Oncology (Williston Park) 2001-02-08

...BRCA2 genes, or with strong family histories of breast/ovarian cancer) is a reasonable approach and may result in accept...

Reduced ligation during DNA base excision repair supported by BRCA2 mutant ce...

Bogliolo(M),Taylor(R M),Caldecott(K W),Fro... Oncogene 2001-01-04

...BRCA2 appear to be involved in DNA repair. In particular, the sensitivity of BRCA2-deficient mouse embryonic fibroblasts...

Absence of rearrangements in the BRCA2 gene in human cancers.

Chin(S F),Wang(Q),Puisieux(A),Caldas(C) Br J Cancer 2001-03-08

Mutations of BRCA2 in sporadic breast and ovarian carcinomas are exceedingly rare. This led to the suggestion that large...

Inherited genetic susceptibility to breast cancer.

Chang-Claude(J) IARC Sci Publ 2001-04-19

...BRCA2, which were identified using linkage analysis in large extended breast and/or ovarian cancer pedigrees, are estima...

The frequency of the predominant Jewish mutations in BRCA1 and BRCA2 in unsel...

Chen-Shtoyerman(R),Figer(A),Fidder(H H),Ra... Br J Cancer 2001-04-05

...BRCA2). A total of four carriers was found (4/225, 1.78%). This frequency is similar to the estimated normal Ashkenazi p...

The rate of the 6174delT founder Jewish mutation in BRCA2 in patients with no...

Figer(A),Irmin(L),Geva(R),Flex(D),Sulkes(J... Br J Cancer 2001-04-05

...BRCA2 might be associated with an increased risk for various GI malignancies. A single mutation (6174delT) occurs in the...

Screening of male breast cancer and of breast-ovarian cancer families for BRC...

Pages(S),Caux(V),Stoppa-Lyonnet(D),Tosi(M) Br J Cancer 2001-04-05

...BRCA2 protein. This study indicates a BRCA2 contribution of 10% (95% CI 2.5-17.5) to our original cohort of 59 breast-ov...

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