...BRCA2 were identified. The diagnosis made was prostate cancer associated with hereditary breast and ovarian cancer syndr...
...BRCA2 sv.7-sv.56), expanding the known transcript repertoire of BRCA2 gene. Notably, transcript variants sv.9, sv.15, an...
...Brca2-/-, BPPNM, and KPCA), tumors preferentially seed adipose-associated regions despite the absence of mature adipocyt...
...BRCA2 variants (c.5576_5579delTTAA, p. Ile1859Lysfs*3, and c.9357A>C,p. Leu 3119 Phe) were identified, which were inheri...
...BRCA2 c.156_157insAlu variant was identified in 6 individuals (25% of all BRCA2 pathogenic variants identified), includi...
...BRCA2. Germline testing performed in 15 cases identified Lynch syndrome in 5 (33%). MMR immunohistochemistry performed o...
...BRCA2 RAD51-binding domain (RAD51-BD) mutations (HR, 0.29; 95% CI, 0.11-0.79; P = 0.010). BRCA1 BRCT1 mutations are asso...
BRCA1 and BRCA2 proteins are crucial for DNA repair through homologous recombination (HR), which predominantly takes pla...
...BRCA2 are essential for homologous recombination (HR) repair. Mutations in BRCA1/2 compromise HR repair efficacy, result...
...BRCA2, and HSD3B1 are the most prevalent alterations in men with advanced prostate cancer and are associated with increa...
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