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DNA double-strand breaks: signaling, repair and the cancer connection.

Khanna(K K),Jackson(S P) Nat Genet 2001-04-12

...Brca2 have been linked to such pathways, and how accumulating evidence is connecting deficiencies in cellular responses ...

A probability model for predicting BRCA1 and BRCA2 mutations in breast and br...

Vahteristo(P),Eerola(H),Tamminen(A),Blomqv... Br J Cancer 2001-04-19

Germline mutations in BRCA1 and BRCA2 genes predispose to hereditary breast and ovarian cancer. Our aim was to find asso...

Germ line mutations associated with breast cancer susceptibility.

Iau(P T),Macmillan(R D),Blamey(R W) Eur J Cancer 2001-03-29

...BRCA2 genes are the most clinically relevant, much of the data on which clinical decisions are based must be interpreted...

Chromosomal instability in BRCA1- or BRCA2-defective human cancer cells detec...

Ban(S),Shinohara(T),Hirai(Y),Moritaku(Y),C... Mutat Res 2001-04-12

The BRCA1 and BRCA2 gene products are believed to play an important part in the onset and/or development of many sporadi...

BRCA2 is required for homology-directed repair of chromosomal breaks.

Moynahan(M E),Pierce(A J),Jasin(M) Mol Cell 2001-04-12

The BRCA2 tumor suppressor has been implicated in the maintenance of chromosomal stability through a function in DNA rep...

Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

Davies(A A),Masson(J Y),McIlwraith(M J),St... Mol Cell 2001-04-12

...BRCA2 mutations are predisposed to breast and ovarian cancers. Here, we show that BRCA2 plays a dual role in regulating ...

Familial breast cancer in southern Taiwan.

Hou(M F),Tsai(K B),Fan(H M),Wang(C Y),Lin(... Kaohsiung J Med Sci 2001-12-04

...BRCA2 related cases. Patients were compared with 425 non-familial sporadic cases. Familial breast cancer patients had si...

A genetic epidemiological study of carcinoma of the fallopian tube.

Aziz(S),Kuperstein(G),Rosen(B),Cole(D),Ned... Gynecol Oncol 2001-03-29

...BRCA2.,A modest increase in the risk of ovarian cancer (relative risk (RR) = 2.2; 95% confidence interval (CI) = 0.4, 6....

Risk of endometrial carcinoma associated with BRCA mutation.

Levine(D A),Lin(O),Barakat(R R),Robson(M E... Gynecol Oncol 2001-03-29

Inherited mutations in the BRCA1 or BRCA2 genes are associated with a greatly increased lifetime risk of breast and ovar...

Two BRCA1-positive epithelial ovarian tumors with metastases to the central n...

Koul(A),Loman(N),Malander(S),Borg (A),Ridd... Gynecol Oncol 2001-03-29

...BRCA2 mutations in the south of Sweden (results published). A retrospective follow-up revealed that 2 of these (2/37; 5....

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