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TP53 BRCA1 CRISPR single-cell cancer

Runnebaum(I B),Wang-Gohrke(S),Vesprini(D),... Pharmacogenetics 2001-12-26

...BRCA2 carriers with a prior diagnosis of ovarian cancer, 392 carriers with a diagnosis of breast cancer and 249 carriers...

Orelli(B J),Bishop(D K) Breast Cancer Res 2001-11-01

...BRCA2 in DNA repair. Moynahan et al provide genetic data indicating a requirement for BRCA2 in homology-dependent (recom...

Marsh(A),Spurdle(A B),Turner(B C),Fereday(... Breast Cancer Res 2001-11-01

...BRCA2 account for approximately 50% of breast cancer families with more than four affected cases, whereas exonic mutatio...

Verhoog(L C),van den Ouweland(A M),Berns(E... Eur J Cancer 2001-12-04

...BRCA2 (n=21; 4%). BRCA1/2 mutations were found in 72 (52%) of 138 families with breast and ovarian cancer (HBOC), in 43 ...

Hartge(P),Struewing(J P),Wacholder(S),Brod... Am J Hum Genet 2000-04-05

Three founder mutations in the cancer-associated genes BRCA1 and BRCA2 occur frequently enough among Ashkenazi Jews to w...

Eisinger(F),Alby(N),Bremond(A),Dauplat(J),... Bull Cancer 2000-06-08

...BRCA2 germline mutations. Despite the uncertainty, consensus guidelines were defined to assist practitioners', and patie...

Weber(B L),Nathanson(K L) Eur J Cancer 2000-08-03

...BRCA2, have been identified, and the prevalence and penetrance of mutations in these genes have been studied extensively...

Holschneider(C H),Berek(J S) Semin Surg Oncol 2000-08-23

...BRCA2 tumor suppressor genes responsible for the majority of hereditary ovarian cancer. Additional risk factors include ...

Sekine(M),Tanaka(K) Nihon Rinsho 2000-10-19

...BRCA2 are reported to account for around 50% of familial ovarian cancer families. In this paper, we describe the contrib...

Yu(V P),Koehler(M),Steinlein(C),Schmid(M),... Genes Dev 2000-07-24

...Brca2 has an essential function in suppressing GCR formation after chromosome breakage. Cells that harbor truncated Brca...

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