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TP53 BRCA1 CRISPR single-cell cancer

Gayther(S A),de Foy(K A),Harrington(P),Pha... Cancer Res 2000-09-14

...BRCA2) are known to confer an increased risk of prostate cancer of about 3-fold and 7-fold, respectively, in breast canc...

Unger(M A),Nathanson(K L),Calzone(K),Antin... Am J Hum Genet 2000-10-31

...BRCA2 coding-region mutations. An affected individual from each family was tested by PCR for the exon 13 duplication (Pu...

Leong(T),Whitty(J),Keilar(M),Mifsud(S),Ram... Int J Radiat Oncol Biol Phy... 2000-12-07

...BRCA2.,These early results suggest that genes other than BRCA1 and BRCA2 probably account for most cases of clinical rad...

Gorgoulis(V G),Kotsinas(A),Zacharatos(P),M... Cancer 2000-11-21

...BRCA2 locus may be associated with a "gene dosage effect" of BRCA2 function. Little is known about BRCA2 allelic alterat...

Pichert(G),Stahel(R A) J Clin Oncol 2000-11-30

...BRCA2 mutation patterns and the identification of potentially unique mutations in probands who seek genetic counseling a...

Eeles(R A),Powles(T J) J Clin Oncol 2000-11-30

BRCA1 and BRCA2 breast cancer predisposition gene mutation carriers are at markedly increased risk of breast and other c...

Rebbeck(T R) J Clin Oncol 2000-11-30

The availability of genetic testing for inherited mutations in the BRCA1 and BRCA2 genes provides potentially valuable i...

Phillips(K A) J Clin Oncol 2000-11-30

...BRCA2, may provide further insight into this concept. Multiple studies have confirmed that BRCA1-associated HBC (BRCA1-H...

Verhoog(L C),Berns(E M),Brekelmans(C T),Se... J Clin Oncol 2000-11-30

...BRCA2-associated breast cancer. Two studies showed a statistically significant worse survival for BRCA2 patients, but th...

Healey(C S),Dunning(A M),Teare(M D),Chase(... Nat Genet 2000-12-13

...BRCA2, are candidates for this role. BRCA2 is thought to be involved in DNA double strand break-repair. Few mice in whic...

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