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TP53 BRCA1 CRISPR single-cell cancer

Gershoni-Baruch(R),Dagan(E),Fried(G),Kepte... Eur J Hum Genet 2000-01-20

...BRCA2 (6174delT) that account for the overwhelming majority of BRCA mutations in high-risk Jewish families. Among women ...

Bay(J O),Uhrhammer(N),Pernin(D),Presneau(N... Hum Mutat 2000-01-24

...BRCA2 loci. BRCA2 is not likely to be a cancer-predisposing gene in this family because each sister inherited different ...

Spain(B H),Larson(C J),Shihabuddin(L S),Ga... Proc Natl Acad Sci U S A 2000-01-06

BRCA2 mutations predispose carriers mainly to breast cancer. The vast majority of BRCA2 mutations are predicted to resul...

Jernström(H),Lerman(C),Ghadirian(P),Lynch(... Lancet 2000-02-29

...BRCA2 germline mutations. We aimed to establish whether pregnancy is a risk factor for hereditary breast cancer.,We did ...

Verhoog(L C),Brekelmans(C T),Seynaeve(C),D... J Clin Oncol 2000-01-18

...BRCA2 carriers and 75% for sporadic cases (P =.50). At the time of diagnosis, tumors from the BRCA2 carriers were border...

Phillips(K A),Andrulis(I L),Goodwin(P J) J Clin Oncol 2000-01-18

To review the preclinical and clinical studies relevant to the prognosis and prognostic associations of BRCA1- and BRCA2...

Chen(C F),Chen(P L),Zhong(Q),Sharp(Z D),Le... J Biol Chem 2000-01-03

BRCA2 is a breast tumor suppressor with a potential function in the cellular response to DNA damage. BRCA2 binds to Rad5...

Mironov(N),Jansen(L A),Zhu(W B),Aguelon(A ... Carcinogenesis 2000-01-03

We have investigated frameshift mutations in exonic repeats in the ATR, BRCA1, BRCA2, PTCH, CTCF, Cx26, NuMa and TGFbeta...

Gayther(S A),Russell(P),Harrington(P),Anto... Am J Hum Genet 2000-10-02

To establish the contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer, we have analyzed both ge...

Turner(B C),Harrold(E),Matloff(E),Smith(T)... J Clin Oncol 2000-01-04

...BRCA2 (BRCA1/2) mutations, the outcome of treatment with LRT with respect to IBTR has not been determined. In this study...

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