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TP53 BRCA1 CRISPR single-cell cancer

Bay(J O),Uhrhammer(N),Pernin(D),Presneau(N... Hum Mutat 2000-01-24

...BRCA2 loci. BRCA2 is not likely to be a cancer-predisposing gene in this family because each sister inherited different ...

Chen(C F),Chen(P L),Zhong(Q),Sharp(Z D),Le... J Biol Chem 2000-01-03

BRCA2 is a breast tumor suppressor with a potential function in the cellular response to DNA damage. BRCA2 binds to Rad5...

Verhoog(L C),Brekelmans(C T),Seynaeve(C),D... J Clin Oncol 2000-01-18

...BRCA2 carriers and 75% for sporadic cases (P =.50). At the time of diagnosis, tumors from the BRCA2 carriers were border...

Phillips(K A),Andrulis(I L),Goodwin(P J) J Clin Oncol 2000-01-18

To review the preclinical and clinical studies relevant to the prognosis and prognostic associations of BRCA1- and BRCA2...

Gayther(S A),Russell(P),Harrington(P),Anto... Am J Hum Genet 2000-10-02

To establish the contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer, we have analyzed both ge...

Hartge(P),Struewing(J P),Wacholder(S),Brod... Am J Hum Genet 2000-04-05

Three founder mutations in the cancer-associated genes BRCA1 and BRCA2 occur frequently enough among Ashkenazi Jews to w...

Bennett(L M),McAllister(K A),Blackshear(P ... Mol Carcinog 2000-09-05

...Brca2 genes is interdependent. The interdependence of Brca1 and Brca2 was evaluated by studying Brca2 gene expression in...

Gao(Q),Tomlinson(G),Das(S),Cummings(S),Sve... Hum Genet 2000-10-27

...BRCA2. The spectrum of mutations was unique in that one novel BRCA1 mutation (1625del5) and three novel BRCA2 mutations ...

Moslehi(R),Russo(D),Phelan(C),Jack(E),Antm... Clin Genet 2000-04-28

Currently many centers offer testing for three specific mutations, 185delAG, 5382insC, and 6174delT, in the BRCA1 and BR...

Futamura(M),Arakawa(H),Matsuda(K),Katagiri... Cancer Res 2000-05-04

...BRCA2, we used a yeast two-hybrid system to screen for proteins that could associate with BRCA2. Here we report interact...

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