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Identification of Patients at Elevated Cancer Risk through a Community-Based ...

Brabender(D),Siegel(E),Culver(JO),Comeaux(... Ann Surg Oncol 2025-11-00

...BRCA2 (8%), APC I1370K (8%), and Lynch Syndrome-associated (7%). Among those positive for a P/LP variant, individuals we...

Trends in the Utilization of BRCA1 and BRCA2 Testing After the Introduction o...

Dossa(F),Baxter(NN),Sutradhar(R),Little(T)... Curr Oncol 2025-08-06

...BRCA2 testing use after implementation of a publicly funded testing program. We conducted a retrospective, near populati...

Multi-omics analysis uncovers predictive biomarkers for the efficacy and outc...

Ni(J),Li(C),Xu(X),Xu(Q),Yin(Q),Chen(H),Zho... BMC Med 2025-07-22

...BRCA2, cytokine genes, and high tumor mutation burden were significantly associated with treatment response. In contrast...

DSS1 inhibits autophagy to activate epithelial-mesenchymal transition in a pr...

Chen(X),Liu(Q),Wu(J),Zhou(P),Zhao(M),Song(... Nat Commun 2025-07-23

...BRCA2 in DNA repair, is upregulated in metastatic ccRCC and promotes both tumor growth and distant metastasis. Mechanist...

Pathologic complete response after neoadjuvant chemotherapy for HER-2 negativ...

Chen(X),Ji(L),Fan(Y),Li(Q),Li(Q),Wang(J),L... Future Oncol 2025-08-00

...BRCA2 (31.3%), and other HRR genes (26.6%). Hormone receptor positive patients accounted for 55.9% (118/211). Half of th...

Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous ...

Deveryshetty(J),Mistry(A),Pangeni(S),Ghone... Nat Commun 2025-07-21

...BRCA2 (humans) for Rad51 loading. The mechanisms of this exchange remain unclear. We show that Saccharomyces cerevisiae ...

Functional Disruption of IQGAP1 by Truncated PALB2 in Two Cases of Breast Can...

Pérez-Rodríguez(ND),Martín-Ramírez(R),Gonz... Biomedicines 2025-07-23

...BRCA2 homologous recombination repair complex, are associated with increased risk and aggressiveness of breast cancer. T...

Breast biopsies and breast cancer risk in Israeli BRCA germline pathogenic va...

Madorsky Feldman(D),Sklair-Levy(M),Laitman... Breast Cancer Res Treat 2025-10-00

...BRCA2 pathogenic variants (PVs) carriers. Female BRCA1 and BRCA2 PV carriers treated at the Meirav Clinic, Sheba Medical...

The use of hormonal contraceptives in a cohort of healthy women with BRCA mut...

Grandi(G),Sgandurra(A),Feliciello(L),Pedri... Eur J Contracept Reprod Hea... 2025-12-00

...BRCA2), in comparison to similar women of the same cohort who were not using HC or had recently undergone risk-reducing ...

Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired m...

Wu(X),Zhang(Q),Li(C),Zhuang(S),Liu(H),Jiao... Commun Biol 2025-07-25

...BRCA2), which participates in homologous recombination (HR), is a key regulator of natural menopause. Rare BRCA2 variant...

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