Germ line mutations in the breast cancer susceptibility gene BRCA2 predispose to early-onset breast cancer, but the func...
...BRCA2, therefore, it appears that LKB1 mutations can cause ovarian tumours when present in the germline, but occur rarel...
...BRCA2 genes are located, indicates that BRCA1 and BRCA2 act as tumor suppressor genes. The list of identified germline m...
...BRCA2--has received a lot of publicity. Public and professional expectations of the availability and utility of genetic ...
Inheritance of germ-line mutant alleles of BRCA1 and BRCA2 confers a markedly increased risk of breast cancer and we hav...
...BRCA2 gene. Our findings indicate an increased probability of detecting a BRCA gene mutation when ovarian cancer occurre...
...BRCA2 (61%), RB1 (67%), or TP53 (73%). No instance of TP53 LOH was observed without simultaneous allelic imbalance at th...
...BRCA2 locus. Deletion of regions on chromosome 13q containing the BRCA2 and RB1 genes has also been reported in sporadic...
...BRCA2. Since the sequencing of these genes, considerable research on the genetics of the mutation carriers has been perf...
...BRCA2 protein, etc. These proteins likely mediate the involvement of BRCA1 in DNA repair, transcriptional transactivatio...
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