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Mutations in the RAD54 recombination gene in primary cancers.

Matsuda(M),Miyagawa(K),Takahashi(M),Fukuda... Oncogene 1999-06-28

...BRCA2 suggests that defects in homologous recombination are responsible for tumor formation. Also recent findings that a...

Increased level of exon 12 alternatively spliced BRCA2 transcripts in tumor b...

Bièche(I),Lidereau(R) Cancer Res 1999-06-29

...BRCA2 expression in breast tissue, we analyzed full-length BRCA2 mRNA by means of reverse transcriptase-PCR with a panel...

Screening for breast and ovarian cancer: the relevance of family history.

Pharoah(P D),Stratton(J F),Mackay(J) Br Med Bull 1999-06-25

...BRCA2--has received a lot of publicity. Public and professional expectations of the availability and utility of genetic ...

BRCA1 and BRCA2 in breast cancer.

Yang(X),Lippman(M E) Breast Cancer Res Treat 1999-08-05

...BRCA2 genes are located, indicates that BRCA1 and BRCA2 act as tumor suppressor genes. The list of identified germline m...

Germline brca2 sequence variants in patients with ocular melanoma.

Sinilnikova(O M),Egan(K M),Quinn(J L),Bout... Int J Cancer 1999-07-27

...brca2 germline mutations, we examined the frequency of brca2 alterations in a series of 62 ocular melanoma cases. These ...

Common mutations in BRCA1 and BRCA2 do not contribute to early prostate cance...

Nastiuk(K L),Mansukhani(M),Terry(M B),Kula... Prostate 1999-08-17

...BRCA2, appear to have a higher incidence of prostate cancer among male relatives. We aimed to determine whether the comm...

Linkage analysis and loss of heterozygosity for chromosome arm 1p in familial...

Millikan(R C),Ingles(S A),Diep(A T),Xue(S)... Genes Chromosomes Cancer 1999-08-05

...BRCA2. We also investigated loss of heterozygosity for a panel of markers on chromosome arm 1p using breast tumors from ...

The BRCA2 transactivation domain does not interact with JNK.

May(G H),Harris(F),Gillespie(D),Black(D M) Genes Chromosomes Cancer 1999-08-05

...BRCA2, our findings indicate that BRCA2 is not regulated by the JNK pathway in a manner analogous to JUN. Genes Chromoso...

Recommendations for medical management of hereditary breast and ovarian cance...

Eisinger(F),Alby(N),Bremond(A),Dauplat(J),... Ann Oncol 1999-02-04

Almost 10% of breast and ovarian cancers are familial, and the majority are linked to BRCA1 and BRCA2 germline mutations...

Epidemiology, prevention, and early detection of breast cancer.

Alberg(A J),Visvanathan(K),Helzlsouer(K J) Curr Opin Oncol 1999-01-06

...BRCA2, more data are needed to understand the risks associated with specific mutations, optimal implementation of geneti...

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