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Laboratory determination of hereditary susceptibility to breast and ovarian c...

Frank(T S) Arch Pathol Lab Med 1999-11-30

Inherited mutations in the genes BRCA1 and BRCA2 are associated with a significantly increased risk of breast cancer, pa...

Accumulation of p53 protein is frequent in ovarian cancers associated with BR...

Zweemer(R P),Shaw(P A),Verheijen(R M),Ryan... J Clin Pathol 1999-11-16

...BRCA2 related ovarian cancers.,In addition to germline BRCA1 and BRCA2 mutations, somatic p53 alterations leading to p53...

Identification and characterization of a transcriptional silencer upstream of...

Sharan(C),Hamilton(N M),Parl(A K),Singh(P ... Biochem Biophys Res Commun 1999-12-20

...BRCA2 silencer-binding proteins in the breast cell extracts indicates the potential regulation of BRCA2 gene expression ...

Breast cancer: genetic predisposition and exposure to radiation.

Bennett(L M) Mol Carcinog 1999-12-02

...BRCA2, ATM, and p53, has been accompanied by the examination of the effects of radiation in combination with genetic mut...

Population-based estimate of the average age-specific cumulative risk of brea...

Hopper(J L),Southey(M C),Dite(G S),Jolley(... Cancer Epidemiol Biomarkers... 1999-11-10

...BRCA2), only 5 (1 BRCA1 and 4 BRCA2) had at least one affected relative, so family history of breast cancer was not a st...

Genetic aspects of hepatocellular carcinogenesis.

Ozturk(M) Semin Liver Dis 1999-11-04

...BRCA2 have also been reported. Oncogenic activation of several cellular genes such as cyclin D and cyclin A have been de...

Overexpression of BRCA2 gene in sporadic breast tumours.

Bièche(I),Noguès(C),Lidereau(R) Oncogene 1999-10-21

...BRCA2 expression in sporadic breast cancer, we quantified BRCA2 mRNA by means of RT - PCR in a large series of human pri...

Progress in cancer genetics: lessons from pancreatic cancer.

Goggins(M),Kern(S E),Offerhaus(J A),Hruban... Ann Oncol 1999-09-09

...BRCA2 gene are present in 5-10% of patients with pancreatic cancer. Typically such patients do not have a family history...

Pathology of incipient pancreatic cancer.

Hruban(R H),Wilentz(R E),Goggins(M),Offerh... Ann Oncol 1999-09-09

...BRCA2.,From these morphologic and molecular observations, we can now develop a progression model for the development of ...

Familial pancreatic cancer.

Hruban(R H),Petersen(G M),Goggins(M),Tersm... Ann Oncol 1999-09-09

...BRCA2 have been shown to predispose to both breast and pancreatic cancer, germline mutations in p16 to melanoma and panc...

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