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Public health aspects of breast cancer gene testing in Canada. Part 1: risks ...

Elwood(J M) Chronic Dis Can 1999-08-03

...BRCA2 genes are high, but it is likely that estimates based on selected large multicase families are inflated by selecti...

Risk factors for detecting germline BRCA1 and BRCA2 founder mutations in Ashk...

Hodgson(S V),Heap(E),Cameron(J),Ellis(D),M... J Med Genet 1999-08-24

...BRCA2 (6174delT). Personal/family histories were correlated with mutation status. Logistic regression was used to develo...

Molecular characterization of germline mutations in the BRCA1 and BRCA2 genes...

Li(S S),Tseng(H M),Yang(T P),Liu(C H),Teng... Hum Genet 1999-05-21

...BRCA2 protein translation. Several genetic polymorphisms in both BRCA1 and BRCA2 genes were also detected in this invest...

Expression of human estrogen receptor using an efficient adenoviral gene deli...

Lazennec(G),Katzenellenbogen(B S) Mol Cell Endocrinol 1999-08-20

...BRCA2 genes, which is in agreement with their mitogenic-dependent expression, while expression of beta-actin, a housekee...

Founder BRCA1 and BRCA2 mutations in French Canadian ovarian cancer cases uns...

Tonin(P N),Mes-Masson(A M),Narod(S A),Ghad... Clin Genet 1999-08-24

The breast cancer susceptibility genes, BRCA1 and BRCA2, differ in their contribution to ovarian cancer. Recently, found...

The pros and cons of genetic testing for breast and ovarian cancer risk.

Frank(T S),Braverman(A M) Int J Fertil Womens Med 1999-10-26

Nearly 10% of breast and ovarian cancers develop as a direct consequence of an inherited flaw in the genes BRCA1 and BRC...

Cancer risks in BRCA2 mutation carriers.

J Natl Cancer Inst 1999-11-18

Carriers of germline mutations in the BRCA2 gene are known to be at high risk of breast and ovarian cancers, but the ris...

The genetic components of susceptibility to breast cancer in the rat.

Shepel(L A),Gould(M N) Prog Exp Tumor Res 1999-07-15

...BRCA2 in human breast cancer is due to loci that modify the effects of the sensitivity genes. Assuming that human homolo...

Prevalence and penetrance of BRCA1 and BRCA2 gene mutations in unselected Ash...

Warner(E),Foulkes(W),Goodwin(P),Meschino(W... J Natl Cancer Inst 1999-08-19

Approximately 2.0%-2.5% of Ashkenazi Jewish women carry one of three founding mutations in the BRCA1 and BRCA2 genes, an...

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in...

Yuan(S S),Lee(S Y),Chen(G),Song(M),Tomlins... Cancer Res 1999-09-07

...BRCA2 account for the majority of familial breast cancers. Cells with mutated BRCA1 or BRCA2 are hypersensitive to ioniz...

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