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TP53 BRCA1 CRISPR single-cell cancer

Lee(H),Trainer(A H),Friedman(L S),Thistlet... Mol Cell 1999-08-30

...Brca2 gene encodes a nuclear protein implicated in DNA repair. Brca2 behaves as a tumor suppressor, but paradoxically, i...

Noguchi(S),Kasugai(T),Miki(Y),Fukutomi(T),... Cancer 1999-05-27

The purpose of this investigation was to elucidate the clinicopathologic characteristics of BRCA1- and BRCA2-associated ...

Buchholz(T A),Weil(M M),Story(M D),Strom(E... Radiat Oncol Investig 1999-07-12

...BRCA2, or ATM, has been determined to be one mechanism of breast carcinogenesis. It has been established that inherited ...

Moll(U),Lau(R),Sypes(M A),Gupta(M M),Ander... Oncogene 1999-06-08

...Brca2, a human tumor suppressor gene that is implicated in the repair of DNA strand-breaks. Brca2 was strongly expressed...

Carter(C L),Hailey(B J) Women Health 1999-08-19

...BRCA2 genes. Although still largely limited to research programs, widespread commercial testing and incorporation of gen...

Bièche(I),Noguès(C),Rivoilan(S),Khodja(A),... Br J Cancer 1998-01-08

...BRCA2 status (P = 0.34, P = 0.29 respectively). LOH at BRCA2 does not therefore appear to be a major prognostic marker i...

Mavraki(E),Gray(I C),Bishop(D T),Spurr(N K... Br J Cancer 1998-01-08

...BRCA2 mutations; two frameshifts and one putative missense mutation were identified. One of the frameshifts was detected...

Zumoff(B) Proc Soc Exp Biol Med 1998-01-20

...BRCA2, and p53 genes. c. The prevalence of increased 16 alpha-hydroxylation of estradiol. d. The prevalence of smokers w...

Wong(A K),Pero(R),Ormonde(P A),Tavtigian(S... J Biol Chem 1998-01-22

...BRCA2 tumor suppressor protein interacts with the murine RAD51 protein. This interaction suggests that BRCA2 participate...

DeCruz(E E),Walker(T L),Dass(C R),Burton(M A) J Exp Ther Oncol 1998-02-04

...BRCA2) with diverse cancers has also highlighted the potential of somatic gene therapy with wild-type versions of suppre...

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