We examined germline mutations in BRCA1 and BRCA2 in 23 Japanese breast cancer families, using PCR-SSCP analysis. The sa...
...BRCA2 (exon 25 codon 3118; Met3118Thr) was detected in this patient. These data may provide useful information on the ca...
...BRCA2 as causative agents of familial breast cancer was assessed. Their possible involvement in the carcinogenesis of he...
...BRCA2. METHODS: We analyzed 11 breast cancers from 10 patients from 8 Japanese late-onset Breast cancer families. RESULT...
...BRCA2, WT1 and E-cadherin genes were analysed for LOH, and p53 gene was also analysed for the codon 249 mutation, in tum...
...BRCA2, with other genes accounting for a smaller fraction. Women who inherit a mutation in any of these genes are far mo...
...BRCA2 mutation (3034del4bp). We then performed LOH analysis for BRCA2 in lung adenocarcinoma tissue of the patient. Usin...
...BRCA2 mutations. We found a novel nonsense (c.2469G>A, p.W823*) mutation in one patient. In addition, we also found 51 m...
The tumor suppressor gene breast cancer susceptibility gene 2 (BRCA2) is frequently mutated or epigenetically repressed ...
...BRCA2 mutation carriers with breast cancer have a high risk of ipsilateral breast cancer tumor recurrence (IBTR) and a h...
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