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Wei(X),Mansour(L),Oxley(S),Fierheller(CT),... JAMA Oncol 2025-07-24

...BRCA2/PALB2 pathogenic variants. The precise BC risk threshold for offering risk-reducing mastectomy (RRM) for BC preven...

Xu(Y),Qin(C),Zhang(M),Wu(Q),Li(Z),Mo(H),Ch... Am J Pathol 2025-10-00

...BRCA2 and the BRCA1-interacting helicase 1 (BRIP1), and interacted with these proteins to prevent cell death in response...

Zheng(L),Zhu(Q),Zhang(F),Qiu(H),Qin(L),Yan... Front Oncol 2025-00-00

...BRCA2 GDH. The BRCA1/BRIP1 GDH patient is a 46-year-old female diagnosed with advanced ovarian adenocarcinoma at clinica...

Chen(X),Liu(Q),Wu(J),Zhou(P),Zhao(M),Song(... Nat Commun 2025-07-23

...BRCA2 in DNA repair, is upregulated in metastatic ccRCC and promotes both tumor growth and distant metastasis. Mechanist...

Michalczyk(K),Mokrzycka(A),Rudzińska(M),Mi... Genes (Basel) 2025-07-27

Mutations in the BRCA1 and BRCA2 genes are well-known risk factors for ovarian cancer. They are also associated with res...

Yang(X),Yan(T),Wang(Y),Tong(Y),Ma(X),Guo(L... Int J Biol Markers 2025-09-00

...BRCA2, TP53, ATAD2, NY-ESO-1, CAGE) exhibited significant differences (p < 0.001) between benign and malignant breast no...

Apostol(AI),Kotsopoulos(J),Gronwald(J),Kim... Gynecol Oncol 2025-10-00

...BRCA2). The 15-year cumulative ovarian cancer risk was 14.9 % in BRCA1 and 5.1 % in BRCA2 carriers. Women with breast ca...

Beutel(AK),Halbrook(CJ),Ekizce(M),Lindenma... United European Gastroenter... 2025-09-00

...BRCA2 and PALB2-defective versus HR-proficient murine PDAC cells, we systematically investigated the feasibility of expa...

Andour(L),Hagenaars(SC),Vangangelt(K),Aalb... Int J Cancer 2025-08-15

...BRCA2 (n = 29, 29%) carriers. Invasive cancer was diagnosed in 100 cases: 76% (n = 76) had a PV with a median age of 49 ...

Elmetnawy(W),Nader(H),ElNahas(T),Sabet(S),... Sci Rep 2025-07-18

...BRCA2 LPVs; gBRCA2 c.3139del and c.5690 dup were identified. Variants of uncertain significance (VUS) were found in 22 p...