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Crawford(TB),Tayeb(M),Barrett(E),Al-Saleem... medRxiv 2025-08-15

...BRCA2, CHEK2 and Lynch genes were significantly higher compared to two cancer-free male cohorts. BRCA2 and Lynch genes P...

Leone(G),Wong(YNS),Jones(RJ),Sankey(P),Jos... J Clin Oncol 2025-10-00

...BRCA2 loss (4/8), and HII ± other ImS+ features (13/30). Duration of response for patients with HII without other ImS+ f...

Obispo(B),Bailleux(C),Cantos(B),Zamora(P),... Cancers (Basel) 2025-07-30

...BRCA2), (gBRCAm), who are typically young women, often require more aggressive therapeutic interventions. These mutation...

Hyldebrandt(HK),Stormorken(AT),Vitelli(V),... Fam Cancer 2025-07-29

...BRCA2 carriers without prior breast cancer have the option to undergo risk-reducing mastectomy (RRM). The aim of this st...

Lee(Y),Kim(HD),Lee(SY),Lee(H),Hyung(J),Moo... Gastric Cancer 2025-11-00

...BRCA2, BRIP1, MRE11A, NBN, PALB2, PARP1, POLD1, RAD50, RAD51, RAD51C, RAD51D, RAD52, RAD54L, and XRCC2) was assessed usi...

Colin-Leitzinger(C),Lawson-Michod(KA),John... Clin Epigenetics 2025-07-30

...BRCA2 mutations. Two RE methylation clusters were identified. Cluster 1 exhibited a more hypomethylated RE profile ("Act...

Oh(KS),Nam(AR),Bang(JH),Jeong(Y),Choo(SY),... Int J Biol Sci 2025-00-00

...BRCA2-/- PDAC cells. JPI-547 outperformed most PARP inhibitors, with a half-maximal inhibitory concentration approximate...

Nierenberg(JL),Adamson(AW),Hu(D),Huntsman(... Nat Commun 2025-08-21

...BRCA2, and PALB2 strongly associated with BC. FANCM was previously proposed as a possible susceptibility gene for ER-neg...

Fujii(T) Int J Clin Oncol 2025-10-00

Hereditary breast and ovarian cancer (HBOC) syndrome is caused by germline mutations in the BRCA1 and BRCA2 genes, which...

Canson(DM),Parsons(MT),Moir-Meyer(G),Dumen... Genome Res 2025-09-02

BRCA1 and BRCA2 germline variant classification is vital for clinical management of families with hereditary breast and ...