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Trabectedin as a chemotherapy option for patients with BRCA deficiency.

Monk(Bradley J),Lorusso(Domenica),Italiano... Cancer Treat Rev 0000-00-00

...BRCA2. The particular sensitivity of sarcoma, ovarian and breast cancer cells deficient in HRR, previously observed in p...

The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filame...

Kelso(Andrew A),Goodson(Steven D),Watts(Le... Nucleic Acids Res 0000-00-00

...BRCA2, which is complexed with RAD51. Together BRCA2-DSS1 displace RPA and load RAD51 onto the ssDNA. In addition, the B...

Prognostic significance of BRCA mutations in ovarian cancer: an updated syste...

Xu(Kai),Yang(Shouhua),Zhao(Yingchao) Oncotarget 0000-00-00

...BRCA2 mutation carriers, the HRs for OS and PFS benefits were 0.57 (95% CI, 0.45 to 0.73) and 0.48 (95% CI, 0.30 to 0.75...

Utilizing fluorescent life time imaging microscopy technology for identify ca...

Zahavi(Tamar),Yahav(Gilad),Shimshon(Yael),... Biochem Biophys Res Commun 0000-00-00

...BRCA2 mutations is of great importance. The available diagnostic tests for mutation analysis of BRCA1 and BRCA2 are time...

Engineering Archeal Surrogate Systems for the Development of Protein-Protein ...

Moschetti(Tommaso),Sharpe(Timothy),Fischer... J Mol Biol 0000-00-00

...BRCA2. As human RAD51 has proved impossible to produce in a form that is compatible with the requirements of fragment-ba...

Synchronous Onset of Breast and Pancreatic Cancers: Results of Germline and S...

Castro(Michael),Vierkoetter(Koah),Prager(D... Case Rep Oncol 0000-00-00

...BRCA2 mutation to a patient who was diagnosed at age 40 with locally advanced breast and pancreas cancer is presented. S...

Integrated analysis of gene expression and methylation profiles of 48 candida...

Li(Zibo),Heng(Jianfu),Yan(Jinhua),Guo(Xinw... Breast Cancer Res Treat 0000-00-00

...BRCA2, CADM1, CAV1, CCND2, CST6, EGFR, ESR2, GSTP1, ICAM5, NPY, PGR, PTGS2, RECK, RUNX3, SFRP1, SOX17, SYK, TGFBR2, TNFR...

Early onset breast cancer in Ashkenazi women carriers of founder BRCA1/2 muta...

Dagan(E),Gershoni-Baruch(R),Kurolap(A),Fri... Eur J Cancer Care (Engl) 0000-00-00

...BRCA2 carriers. BRCA2 carriers portrayed similar tumour characteristics to non-carriers. EOBC BRCA1/2 carriers are at ri...

Molecular characterization, homology modeling and docking studies of the R278...

Riahi(Aouatef),Messaoudi(Abdelmonem),Mrad(... J Theor Biol 0000-00-00

...BRCA2 gene) variant as pathogenic. Then, to investigate the functional role of the R2787H variation in altering BRCA2 st...

A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer C...

Liu(Wenpeng),Zhou(Mian),Li(Zhengke),Li(Hon... EBioMedicine 0000-00-00

...BRCA2 and BOD1L. C5 sensitizes cells to CPT and synergizes with PARP inhibitors.

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