...BRCA2). In patients with BRCA-mutated cancers, olaparib blocks vital PARP-mediated tumor cell DNA repair mechanisms, lea...
...BRCA2 The development of poly(adenosine diphosphate-ribose) polymerase inhibitors represents a novel therapeutic strateg...
...BRCA2 germline mutations, we have found the deletion in 35 families (1.68%), representing 7.83% of the mutations identif...
...BRCA2 carrier. NPOS was declined initially due to fear of procedure, surgical/anaesthetic risk, invasiveness and planned...
...BRCA2 interacts with cytoplasmic dynein 1 to localize BRCA2 to the centrosome. In vitro pull-down assays demonstrated th...
...BRCA2 and PALB2. RAD52 also participates in the recovery of the stalled replication forks. Anticipating that ssDNA bindi...
...BRCA2 mutation (110 in BRCA1and 122 in BRCA2) in this cohort of 5931 patients. BRCA1/2 mutation rate was 16.9 % (92/543)...
...BRCA2, was falsely called in all samples due to a homopolymer error. In addition, seven different single-nucleotide subs...
...BRCA2 mutation which has substantial implications for their personal management and that of their relatives. Unfortunate...
...BRCA2 genes were frequently mutated in synchronous lesions of non HGS-EOC. Relapsed disease seems to originate from resi...
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