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Trabectedin as a chemotherapy option for patients with BRCA deficiency.

Monk(Bradley J),Lorusso(Domenica),Italiano(A… Cancer Treat Rev 0000-00-00

...BRCA2. The particular sensitivity of sarcoma, ovarian and breast cancer cells deficient in HRR, previously observed in p...

Whole-exome sequencing and targeted gene sequencing provide insights into the r…

Silvestri(Valentina),Zelli(Veronica),Valenti… Cancer 0000-00-00

...BRCA2 mutations account for about 10% of all MBC cases. Thus, a fraction of MBC cases are expected to be due to genetic ...

Assessment of the InSiGHT Interpretation Criteria for the Clinical Classificati…

Tricarico(Rossella),Kasela(Mariann),Mareni(C… Hum Mutat 0000-00-00

...BRCA2 genes. We also observed that the addition of only few clinical data was sufficient to obtain a more stable classif...

Mismatch Repair Polymorphisms as Markers of Breast Cancer Prevalence in the Bre…

Kappil(Maya),Terry(Mary Beth),Delgado-Cruzat… Anticancer Res 0000-00-00

...BRCA2, have been identified. However, mutations in these genes account for only 5-10% of identified breast cancer cases....

Risk reduction and survival benefit of prophylactic surgery in BRCA mutation ca…

Ludwig(Kandice K),Neuner(Joan),Butler(Annabe… Am J Surg 0000-00-00

...BRCA2 genes results in an elevated risk for developing both breast and ovarian cancers over the lifetime of affected car...

Frequent alterations of homologous recombination repair pathway in primary and …

Dasgupta(Hemantika),Mukherjee(Nupur),Islam(S… Future Oncol 0000-00-00

...BRCA2, FANCC and FANCD2 were analyzed in pretherapeutic/neoadjuvant chemotherapy (NACT)-treated BC samples.,Alterations ...

Clinically Significant Unclassified Variants in BRCA1 and BRCA2 Genes Among Kor…

Yoon(Kyong-Ah),Park(Boyoung),Lee(Byung Il),Y… Cancer Res Treat 0000-00-00

...BRCA2. Among 15 candidates genotyped in healthy controls, c.5339T>C in BRCA1 and c.6029T>G, c.7522G>A in BRCA2 were not ...

Pathologic findings at risk-reducing salpingo-oophorectomy (RRSO) in germline B…

Lee(Young Jae),Lee(Shin Wha),Kim(Kyu Rae),Ju… J Gynecol Oncol 0000-00-00

...BRCA2 mutation carriers, precursor lesions were only detected in those older than 40 years of age, indicating the possib...

Novel BRCA2-Interacting Protein, LIMD1, Is Essential for the Centrosome Localiz…

Hou(Xiaobin),Li(Tinghui),Ren(Zhipeng),Liu(Ya… Oncol Res 0000-00-00

...BRCA2 and to explore its functional roles in EC. A yeast two-hybrid screening was performed to identify a novel BRCA2-in...

The status of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors i…

Miller(Rowan E),Ledermann(Jonathan A) Clin Adv Hematol Oncol 0000-00-00

...BRCA2 mutations. However, it is becoming increasingly evident that tumors that share molecular features with BRCA-mutant...

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