The BRCA1 and BRCA2 genes encode critical proteins in the homologous recombination (HR) DNA repair pathway. While their ...
...BRCA2-deficient HGSC and loss of NF1 survived twice as long as those without NF1 loss, whereas PIK3CA or RAD21 amplifica...
...Brca2-deficient mouse ovarian cancer models, ID8-OR and HGS2-OR. HGS2-OR cells had higher RAD52 expression than parental...
...BRCA2, and RPA4, and showed a 70% increase in NAF1 mutant allele frequency. Pathway analysis revealed MSP-RON and NF-κB ...
Hereditary breast and ovarian cancer syndrome (HBOC) is traditionally associated with mutations in the BRCA1 and BRCA2 g...
...BRCA2 PVs, respectively. Risk-reducing salpingo-oophorectomy (RRSO) is a recommended preventive strategy that reduces th...
...BRCA2 mutations typically result in luminal-type disease. Key risk management strategies include surveillance and prophy...
...BRCA2 variants. A total of 264 BRCA1/BRCA2 variants were detected. Of these, 130 (49.2%) were pathogenic variants (PV), ...
...BRCA2 mutations. Here, we describe the discovery and preclinical development of RP-2119, a selective, potent, and bioava...
...BRCA2 frameshift mutation (c.7177dupA), an ATM nonsense mutation, and Tier II mutations in TP53 and PTEN. The tumor exhi...
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