...BRCA2 frameshift mutation (c.7177dupA), an ATM nonsense mutation, and Tier II mutations in TP53 and PTEN. The tumor exhi...
...BRCA2 (20 %), as well as clonal mutations affecting TP53 (30 %) and ATRX (10 %), were early events and present across su...
...BRCA2) in cancer result in the absence of RAD51 on damaged DNA, leaving access to alternative exclusively mutagenic repa...
...Brca2-deficient mouse ovarian cancer models, ID8-OR and HGS2-OR. HGS2-OR cells had higher RAD52 expression than parental...
...BRCA2 mutations. Here, we describe the discovery and preclinical development of RP-2119, a selective, potent, and bioava...
...BRCA2 variants. A total of 264 BRCA1/BRCA2 variants were detected. Of these, 130 (49.2%) were pathogenic variants (PV), ...
...BRCA2 was the most frequently mutated gene contrasting with most reports from the country, in which BRCA1 predominates. ...
...BRCA2, PALB2, ATM, CHEK2, BARD1, BRIP1, RAD51C, RAD51D and mismatch repair (MMR) genes (MLH1, MSH2, MSH6 and PMS2) to en...
...BRCA2 gene germ line mutation in three patients. IHC of BRCA was consistent with BRCA2 mutation status.,The family histo...
...BRCA2 genes was transmitted to the paternal cousin, and the same BRCA2 mutation to the younger sister with bilateral bre...
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