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Gastric epithelium from BRCA1 and BRCA2 carriers harbors increased double-str...

Buckley(KH),Dungan(ME),Dinh(K),Kelly(GM),H... bioRxiv 2025-10-03

...BRCA2 have increased gastric cancer (GC) risk. BRCA1 and BRCA2 are tumor suppressor genes involved in promoting homologo...

Pathogenic variants reveal candidate genes for prostate cancer germline testi...

Gheybi(K),Soh(PXY),Jiang(J),Mbeki(TMN),Lou... Nat Commun 2025-10-02

...BRCA2, POLQ, LRP1B and ATM. Besides notable impact of DNA polymerases, including POLG, Fanconi anaemia genes include FAN...

Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsi...

Ebrahimi(E),Sangphukieo(A),Park(HA),Gabori... Nat Commun 2025-10-02

...BRCA2 and ADH1B variants showing effects modified by smoking and alcohol use. Subsite-specific analysis of the HLA regio...

Association of potential biomarkers with clinical outcomes in metastatic trip...

Cortes(J),Lipatov(O),Im(SA),Goncalves(A),L... NPJ Breast Cancer 2025-10-02

...BRCA2 mutation (BRCAm) status, homologous recombination deficiency (HRD) status, and tumor mutational burden (TMB) with ...

Homologous Recombination in Thyroid Tumor Samples.

Spirina(LV),Tsyganov(MM),Chizhevskaya(SY),... Int J Mol Sci 2025-10-06

...BRCA2, and FANCA genes, typically associated with thyroid tumors, were identified in the tissue of papillary thyroid can...

The 9-1-1 complex protects ssDNA gaps in BRCA2-deficient cancer.

Grimsley(HE),Courtemanche(K),Cox(S),McDerm... bioRxiv 2025-10-07

...BRCA2-deficient cells through an ATR-independent mechanism. Loss of 9-1-1 in this context leads to the accumulation of P...

Whole-exome sequencing in Saudi colorectal cancer patients reveals distinct m...

Alatwi(HE),Alharbi(AA),Mir(R),Alzahrani(OR... Front Oncol 2025-00-00

...BRCA2 (61%), TCF7L2 (52%), EGFR (43%), and SOS1 (43%). Compared to TCGA-COADREAD, mutation frequencies were significantl...

Niraparib and abiraterone acetate plus prednisone for HRR-deficient metastati...

Attard(G),Agarwal(N),Graff(JN),Sandhu(S),E... Nat Med 2025-12-00

...BRCA2 alterations; 78% had high-volume metastases; and 16% had received docetaxel. The primary endpoint was met, with a ...

Clinical implications of rare and common variation in preimplantation genetic...

Lencz(T),Bhattacharyya(U),Klausner(L),John... medRxiv 2025-10-09

...BRCA2, and PALB2 resulted in a risk distribution that was essentially disjoint from the non-carriers, regardless of PRS....

Case Report: Fluzoparib combined Exemestane in gBRCA2-mutated HR+/HER2- advan...

Yang(D),Zhang(X),Hu(X),Lin(S),Yu(N),Lin(X)... Front Pharmacol 2025-00-00

...BRCA2 mutation. Following progression on multiple prior therapies including endocrine therapy combined with a CDK4/6 inh...

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