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Loss of heterozygosity for chromosomal regions 15q14-21.1, 17q21.31, and 13q1...

Nowacka-Zawisza(Maria),Forma(Ewa),Walczak(... Med Oncol 2016-07-28

...BRCA2. To evaluate the contribution of RAD51 to sporadic prostate cancer, loss of heterozygosity (LOH) for chromosomal r...

[From poly(ADP-ribose) discovery to PARP inhibitors in cancer therapy].

Schreiber(Valérie),Illuzzi(Giuditta),Héber... Bull Cancer 2016-01-19

...BRCA2, by synthetic lethality. Several phase III clinical trials are in progress for the treatment of breast and ovarian...

Germline Mutations of BRCA1 and BRCA2 in Korean Ovarian Cancer Patients: Find...

Choi(Min Chul),Heo(Jin-Hyung),Jang(Ja-Hyun... Int J Gynecol Cancer 2016-08-04

...BRCA2 UV (8665_8667delGGA) was strongly suspicious to be a deleterious mutation. BRCA1/2 mutations were identified in 11...

BRCA-mutated Invasive Breast Carcinomas: Immunohistochemical Analysis of Insu...

Mohanty(Sambit K),Lai(Jin-Ping),Gordon(Ora... Breast J 2016-08-19

...BRCA2, and 1 dual BRCA1/BRCA2) and 54 cases of sporadic invasive breast carcinomas. The relationship between the IMP3, C...

Component-wise gradient boosting and false discovery control in survival anal...

He(Kevin),Li(Yanming),Zhu(Ji),Liu(Honglian... Bioinformatics 2016-07-25

...BRCA2 pathway SNPs are likely to be associated with overall survival, as reported by previous literature. Moreover, we h...

Exome sequencing reveals frequent deleterious germline variants in cancer sus...

Ellingson(Marissa S),Hart(Steven N),Kalari... Breast Cancer Res Treat 2016-06-01

...BRCA2 (n = 8), CHEK2 (n = 2), FANCA (n = 1), FANCI (n = 1), FANCL (n = 1), FANCM (n = 1), FH (n = 1), MLH3 (n = 1), MUTY...

Moreton Lecture: Imaging in the Age of Precision Medicine.

Thrall(James H) J Am Coll Radiol 2016-07-11

...BRCA2 genes. Imaging is poised to play major roles in the age of precision medicine. The imaging community needs to lear...

Analysis of PALB2 in a cohort of Italian breast cancer patients: identificati...

Vietri(Maria Teresa),Caliendo(Gemma),Schia... Fam Cancer 2016-06-10

...BRCA2 (BRCAX). Genomic DNA was isolated from peripheral blood lymphocytes, PALB2 coding regions and adjacent intronic we...

Large genomic rearrangements in the familial breast and ovarian cancer gene B...

James(Paul A),Sawyer(Sarah),Boyle(Samantha... Fam Cancer 2016-03-08

Large genomic rearrangements (LGRs) account for at least 10% of the mutations in BRCA1 and 5% of BRCA2 mutations in outb...

The role of the prostate cancer gene 3 urine test in addition to serum prosta...

Cremers(Ruben G),Eeles(Rosalind A),Bancrof... Urol Oncol 2016-03-02

...BRCA2 mutation carriers, and 308 noncarriers. The physicians and participants were blinded for the results. Serum PSA le...

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