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TP53 BRCA1 CRISPR single-cell cancer

Newman(B),Liu(E T) Breast Dis 2005-03-21

...BRCA1 was cloned (3). In contrast, BRCA2 was localized to chromosome 13q12-13 two months before the cloning of BRCA1 was...

Baer(R) Breast Dis 2005-03-21

...BRCA1 in vivo. These efforts have already uncovered two interacting proteins: the BRCA1-associated RING domain (BARD1) p...

Snouwaert(J N),Gowen(L C),Lee(V),Koller(B ... Breast Dis 2005-03-21

...BRCA1 is believed to encode a tumor suppressor. Loss of the remaining functional BRCA1 allele, therefore, is one of the ...

Hacia(J G),Brody(L C),Collins(F S) Breast Dis 2005-03-21

...BRCA1 mutations serves as an example of the considerable technical challenge in developing diagnostic tests for all poss...

Monteiro(A N),Humphrey(J S) Breast Dis 2005-03-21

...BRCA1 account for the majority of families with breast and ovarian cancer predisposition. BRCA1 encodes a 1,863 amino ac...

Struewing(J P) Breast Dis 2005-03-21

A restricted number of mutant BRCA1 alleles are present at high frequency in the Ashkenazi Jewish population: 185delAG a...

Rimer(B K),Sugarman(J),Winer(E),Bluman(L G... Breast Dis 2005-03-21

While the cloning of BRCA1 and BRCA2 in 1994 and 1995 engendered great enthusiasm from cancer patients, their families a...

Berry(D A),Parmigiani(G) Breast Dis 2005-03-21

Tests for the presence of mutations of genes BRCA1 and BRCA2 are increasingly available. Genetic testing creates dilemma...

Dressler(L) Breast Dis 2005-03-21

...BRCA1 gene is available commercially and clinically. The information gained from this test impacts not only on the indiv...

MacLennan(Susan E) Breast Dis 2005-03-21

...BRCA1 and BRCA2 gene mutations and their implications for breast cancer risk have led to renewed interest in prophylacti...

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