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From arrest to escape: HIV-1 Vpr cuts a deal.

Cohen(Eric A) Cell Host Microbe 2014-10-08

...SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.

DNA damage repair machinery and HIV escape from innate immune sensing.

Brégnard(Christelle),Benkirane(Monsef),Lague… Front Microbiol 2014-06-24

...SLX4 complex to promote escape from innate immune sensing and, as a side effect, induces replication stress in cycling c...

Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mit…

Sarbajna(Shriparna),Davies(Derek),West(Steph… Genes Dev 2014-06-23

...SLX4/MUS81 and GEN1 depletion. These observations demonstrate that the SLX1-SLX4 nuclease and the SLX4 scaffold play div...

A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair…

Gritenaite(Dalia),Princz(Lissa N),Szakal(Bar… Genes Dev 2014-09-05

...Slx4 that is under stringent control. Cell cycle-dependent phosphorylation of Slx4 by Cdk1 promotes the Dpb11-Slx4 inter...

Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer r…

Kurian(Allison W),Hare(Emily E),Mills(Meredi… J Clin Oncol 2014-08-15

...SLX4 among 141 women without BRCA1/2 mutations. Fourteen participants carried 15 pathogenic variants, warranting a possi...

XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANC…

Klein Douwel(Daisy),Boonen(Rick A C M),Long(… Mol Cell 2014-07-23

...SLX4/FANCP to carry out the unhooking incisions. Efficient recruitment of XPF-ERCC1 and SLX4 to the ICL depends on FANCD...

Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease X…

Hodskinson(Michael R G),Silhan(Jan),Crossan(… Mol Cell 2014-07-23

...SLX4 and its associated nucleases act in DNA crosslink repair. Here, we uncover consequences of mouse Slx4 deficiency an...

Analysis of the novel fanconi anemia gene SLX4/FANCP in familial breast cancer …

Bakker(Janine L),van Mil(Saskia E),Crossan(G… Hum Mutat 2013-07-01

...SLX4 mutation in breast cancer patients, our data indicate that germline mutations in SLX4 are very rare and are unlikel...

The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its inte…

Salewsky(Bastian),Schmiester(Maren),Schindle… Hum Mol Genet 2013-03-26

...SLX4, a protein recently identified as a new FA protein, FANCP, and known to interact with several structure-specific nu...

Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through …

Beck(Halfdan),Nähse-Kumpf(Viola),Larsen(Mari… Mol Cell Biol 2013-01-03

...SLX4/MUS81-mediated DNA double-strand breakage. Fork speed is normalized and DNA double-strand break (DSB) formation is ...

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