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Bhatla(Teena),Dandekar(Smita),Lu(Benjamin ... J Pediatr Hematol Oncol 2016-05-06

...BRCA2 with LOH at that same position in the tumor tissue was also found. Our data provide valuable insight into the geno...

Massink(Maarten P G),Kooi(Irsan E),Martens... BMC Cancer 2016-06-29

...BRCA2, and CHEK2 mutant tumors. Gene expression analyses based on a mRNA immune signature was used to identify samples w...

Kotsopoulos(Joanne),Rosen(Barry),Fan(Isabe... Gynecol Oncol 2016-04-28

...BRCA2 mutations. A status of no residual disease was achieved by 39% of non-carriers and 19% of mutation carriers (P<0.0...

Dean(Michael),Boland(Joseph),Yeager(Meredi... Gigascience 2016-07-25

Germline mutations in the BRCA1 and BRCA2 genes account for 20-25 % of inherited breast cancers and about 10 % of all br...

Alexandrov(Ludmil B),Nik-Zainal(Serena),Si... Nat Commun 2016-05-17

Targeting defects in the DNA repair machinery of neoplastic cells, for example, those due to inactivating BRCA1 and/or B...

Pennisi(Rosa),Ascenzi(Paolo),di Masi(Aless... Biomolecules 2016-07-13

...BRCA2, CHK1, DNA-PKcs, FANCA, and the MRE11/RAD50/NBN complex, have been described to be client proteins of Hsp90, which...

Weiderpass(Elisabete),Tyczynski(Jerzy E) Mol Diagn Ther 2016-09-05

...BRCA2 gene (BRCAm) have a significantly increased risk of developing ovarian cancer. Epidemiology data in large (>500 pa...

Sénéchal(C),Rousset-Jablonski(C) Gynecol Obstet Fertil 2016-08-03

Should all women with BRCA1 or BRCA2 genes mutations be considered at risk of prematurely impaired fertility, and thus s...

Zhang(Feng),Shi(Jiazhong),Bian(Chunjing),Y... Cell Rep 2016-09-20

...BRCA2 disrupt the interaction with PAR and abolish the fast relocation of BRCA2 to DNA lesions. The quickly recruited BR...

Hagelstrom(Robert Tanner),Ford(James),Reis... Pediatr Blood Cancer 2016-06-13

...BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and t...