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Ermolenko(Natalya A),Boyarskikh(Uljana A),... Asian Pac J Cancer Prev 2016-09-26

...BRCA2 genes on an Illumina MiSeq to identify disease-causing mutations in patients with hereditary breast or ovarian can...

O'Connor(Mark J) Mol Cell 2016-03-09

...BRCA2 mutations, represents the first medicine based on this principle, exploiting an underlying cause of tumor formatio...

van den Broek(Alexandra J),Schmidt(Marjank... PLoS One 2016-03-15

...BRCA2 there was a tendency towards a worse breast cancer-specific and overall survival, however, results were heterogene...

Loke(Johnny),Pearlman(Alexander),Upadhyay(... Hum Mol Genet 2016-02-16

Heritable mutations in the BRCA1 and BRCA2 and other genes in the DNA double-strand break (DSB) repair pathway disrupt b...

Varga(Elizabeth),Chao(Elizabeth C),Yeager(... Fam Cancer 2016-06-10

...BRCA2 "R645fs*15″ and MLH1 "E694*". Because constitutional BRCA2 and MLH1 gene mutations are associated with Hereditary ...

Tangutoori(Shifalika),Baldwin(Paige),Sridh... Maturitas 2016-03-31

...BRCA2 mutations. Currently, clinical trials with several PARP inhibitors are being conducted to assess the toxicities, t...

Vietri(Maria Teresa),Caliendo(Gemma),Schia... Fam Cancer 2016-06-10

...BRCA2 (BRCAX). Genomic DNA was isolated from peripheral blood lymphocytes, PALB2 coding regions and adjacent intronic we...

James(Paul A),Sawyer(Sarah),Boyle(Samantha... Fam Cancer 2016-03-08

Large genomic rearrangements (LGRs) account for at least 10% of the mutations in BRCA1 and 5% of BRCA2 mutations in outb...

Tangudu(Naveen K),Verma(Vinod K),Clemons(T... Mol Cancer Ther 2016-02-01

...Brca2/p53-mutant mammary tumors following daily intratumoral treatment with nanoparticles conjugated to c-Myc shRNA. Sec...

Hernan(I),Mañé(B),Borràs(E),de Sousa Dias(... Clin Transl Oncol 2016-04-06

To analyze BRCA1 and BRCA2 genes using a cost-effective and rapid approach based on next generation sequencing (NGS) tec...