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Outcome of neoadjuvant chemotherapy in BRCA1/2 mutation positive women with a...

Mahdi(Haider),Gockley(Allison),Esselen(Kat... Gynecol Oncol 2016-04-12

...BRCA2 mutation had non-significant trend toward longer PFS compared to patients with unknown BRCA or BRCA1 mutation (20....

Targeted Resequencing of 30 Genes Improves the Detection of Deleterious Mutat...

Rajkumar(Thangarajan),Meenakumari(Balaiah)... Asian Pac J Cancer Prev 2016-05-05

We earlier used PCR-dHPLC for mutation analysis of BRCA1 and BRCA2. In this article we report application of targeted re...

Familial Pancreatic Adenocarcinoma.

Petersen(Gloria M) Hematol Oncol Clin North Am 2016-05-02

...BRCA2 and CDKN2A. Genetic risk assessment and testing is already available. Owing to limited experience worldwide, guida...

A Systematic Comparison of Traditional and Multigene Panel Testing for Heredi...

Lincoln(Stephen E),Kobayashi(Yuya),Anderso... J Mol Diagn 2016-06-06

...BRCA2, we also compared variant interpretations in traditional reports to those produced using only non-proprietary reso...

Deleterious BRCA1/2 mutations in an urban population of Black women.

Lynce(Filipa),Smith(Karen Lisa),Stein(Juli... Breast Cancer Res Treat 2016-05-05

...BRCA2 (BRCA1/2) mutations in clinic-based populations of Black women is limited. In order to address this gap, we perfor...

Alteration in PI3K/mTOR, MAPK pathways and Her2 expression/amplification is m...

Mahdi(Haider),Xiu(Joanne),Reddy(Sandeep K)... J Surg Oncol 2016-01-18

...BRCA2 (18% vs. 6% P = 0.09). HER2 gene amplification (17% vs. 4%, P < 0.001) and Her2/neu expression (10% vs. 2%, P < 0....

β-HPV 5 and 8 E6 disrupt homology dependent double strand break repair by att...

Wallace(Nicholas A),Robinson(Kristin),Howi... PLoS Pathog 2016-02-08

...BRCA2). The resulting diminished BRCA1/2 transcription not only leads to lower protein levels but also curtails the abil...

Ovarian cancer in BRCA1/2 mutation carriers: The impact of mutation position ...

Teixeira(Natalia),Mourits(Marian J E),Vos(... Maturitas 2016-05-09

...BRCA2 families, mutation position did not significantly affect the OC risk (HR=1.50, 95%CI=0.74-3.04). However, in the B...

Risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a 3...

Basu(N N),Ingham(S),Hodson(J),Lalloo(F),Bu... Fam Cancer 2016-08-26

BRCA1 and BRCA2 mutation carriers have an increased risk of contralateral breast cancer after primary breast cancer. Ris...

Association of three SNPs in TOX3 and breast cancer risk: Evidence from 97275...

Zhang(Li),Long(Xinghua) Sci Rep 2016-08-02

...BRCA2 mutation carriers. In conclusion, the meta-analysis suggested that three SNPs in TOX3 were significantly associate...

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