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Clinical Sequencing Contributes to a BRCA-Associated Cancer Rediagnosis That ...

Chapman(Jocelyn S),Asthana(Saurabh),Cade(L... J Natl Compr Canc Netw 2016-04-22

...BRCA2 truncating mutation in the tumor, subsequently confirmed to be a germline event. These findings prompted the initi...

BRCA 1/2 gene mutation and gastrointestinal stromal tumours: a potential asso...

Waisbren(Julie),Uthe(Regina),Siziopikou(Ka... BMJ Case Rep 2016-05-23

...BRCA2 8642del3insC mutation who developed prostate cancer, breast cancer and GIST. GIST has been shown to be associated ...

Analyze Association of BRCA2 Arg372His Polymorphism With Ovarian Cancer Risk.

Wang(Cunfang),Yuan(Cunzhong) Int J Gynecol Cancer 2016-08-04

Studies investigating the association between BRCA2 Arg372His polymorphism and ovarian cancer risks have yielded conflic...

A novel role for non-ubiquitinated FANCD2 in response to hydroxyurea-induced ...

Chen(X),Bosques(L),Sung(P),Kupfer(G M) Oncogene 2016-06-07

...BRCA2, is also required for PCNA monoubiquitination in response to HU, suggesting that this function is independent of h...

Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular...

Chantrill(Lorraine A),Nagrial(Adnan M),Wat... Clin Cancer Res 2016-03-31

...BRCA2, PALB2, ATM).,Tumor biopsy and archived tumor samples were collected from 93 patients and 76 were screened. To dat...

Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a mod...

Frankum(Jessica),Moudry(Pavel),Brough(Rach... Oncotarget 2016-02-29

...BRCA2 mutations. By identifying novel predictive biomarkers of tumour cell sensitivity to olaparib, it is possible that ...

Safeguarding genome stability: RASSF1A tumor suppressor regulates BRCA2 at st...

Pefani(Dafni Eleftheria),O'Neill(Eric) Cell Cycle 2016-03-02

...BRCA2, Breast tumor suppressor, has dual functionality promoting not only DNA repair but also preventing DNA lesions at ...

An original phylogenetic approach identified mitochondrial haplogroup T1a1 as...

Blein(Sophie),Bardel(Claire),Danjean(Vince... Breast Cancer Res 2016-04-18

...BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, ...

Prospective evaluation of alcohol consumption and the risk of breast cancer i...

Cybulski(Cezary),Lubinski(Jan),Huzarski(To... Breast Cancer Res Treat 2016-02-04

...BRCA2 mutation. Information regarding baseline daily alcohol consumption was abstracted from a research questionnaire fo...

Gene analysis techniques and susceptibility gene discovery in non-BRCA1/BRCA2...

Aloraifi(Fatima),Boland(Michael R),Green(A... Surg Oncol 2016-02-22

...BRCA2 genes have up to an 85% risk of developing breast cancer in their lifetimes. These patients are candidates for ris...

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