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Mitotic DNA Synthesis Is Differentially Regulated between Cancer and Noncancero…

Graber-Feesl(CL),Pederson(KD),Aney(KJ),Shima… Mol Cancer Res 2019-00-00

...BRCA2, which led to the identification of RAD52 as a key player in this process. Notably, mitotic DNA synthesis is predo...

Germline and somatic mutational variants of Tunisian high grade serous ovarian …

Ammous-Boukhris(N),Abdelmaksoud-Dammak(R),Be… BMC Cancer 2025-10-09

...BRCA2 significantly contribute to ovarian tumorigenesis. This study investigates the genetic landscape of Tunisian patie...

A case report on IDH-mutant astrocytoma, CNS WHO grade 4: multi-omic characteri…

Tang(X),Wei(W),Huang(Y),Zheng(Y),Xu(Y),Li(F) Front Oncol 2025-00-00

...BRCA2, and RPA4, and showed a 70% increase in NAF1 mutant allele frequency. Pathway analysis revealed MSP-RON and NF-κB ...

A comprehensive framework for the management of hereditary breast cancers: guid…

Ekram(S),Al Eissa(MM) Oncol Rev 2025-00-00

...BRCA2, PALB2, TP53 and PTEN, with germline pathogenic or likely pathogenic variants (PVs/LPVs), substantially increase t...

Preventive Measures for Patients with an Elevated Genetic Risk for Gynecologica…

Ditsch(N),Aktas(B),Banys-Paluchowski(M),Spei… Dtsch Arztebl Int 2025-11-14

...BRCA2 gene is approximately 70%. For ovarian cancer, it is approximately 44% and 17%, respectively. Primary prevention i...

Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochrom…

Hassan(O),Pizzagalli(M),Leary(OP),Zepecki(JP… J Biol Chem 2025-10-00

...BRCA2 expression and increases cancer cell sensitivity to DNA-damaging agents. These findings reveal the role of HDAC7 i...

A Reference System for BRCA Mutation Detection Based on Next-Generation Sequenc…

Qu(S),Chen(Q),Yi(Y),Shao(K),Zhang(W),Wang(Y)… J Mol Diagn 2019-00-00

...BRCA2 mutations (55%) were more common than BRCA1 mutations (45%) in Chinese patients. Eliminating duplicates from 19,88...

Clinical background and outcomes of risk-reducing salpingo-oophorectomy for her…

Nomura(H),Sekine(M),Yokoyama(S),Arai(M),Enom… Int J Clin Oncol 2019-09-00

...BRCA2 mutation (B2); and 3 carried both mutations. During a mean follow-up period of 2.6 years (range 0-12.6), one patie...

Pulmonary Embolism Associated with Olaparib in BRCA2-Mutated Prostate Cancer: A…

Ishii(S),Maekawa(S),Amano(F),Kikuchi(D),Ikar… Curr Oncol 2025-09-19

...BRCA2 mutation, who developed PE during olaparib therapy. Diagnostic evaluations included contrast-enhanced computed tom...

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping le…

Zimmermann(M),Murina(O),Reijns(MAM),Agathang… Nature 2018-00-00

...BRCA2-deficient cells are sensitive to inhibitors of poly(ADP-ribose) polymerase (PARP) has spurred the development of c...

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