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A genome-wide association study on medulloblastoma.

Dahlin(AM),Wibom(C),Andersson(U),Bybjerg-Gra… J Neurooncol 2020-04-00

...BRCA2, PALB2, PTCH1, SUFU, TP53, and GPR161. The strongest evidence for association was found for rs201458864 (PALB2, OR...

Precision Medicine Tumor Boards: Clinical Applicability of Personalized Treatme…

Aust(S),Schwameis(R),Gagic(T),Müllauer(L),La… Cancers (Basel) 2020-02-27

...BRCA2 (2%). In 31 patients (70%) a TT was recommended. A total of 12/31 patients (39%) received the recommended therapy....

Exceptional Response to Olaparib in a Patient With Recurrent Ovarian Cancer and…

Randall(M),Burgess(K),Buckingham(L),Usha(L) J Natl Compr Canc Netw 2020-00-00

...BRCA2 genes (BRCA mutations). Little is known, however, about any correlation between the deletion size and location of ...

GeneReader NGS System Is a Useful Sequencing Platform for Clinical Testing of B…

Lee(EJ),Kim(HK),Ahn(S),Lee(YJ),Kim(J),Lee(SW… Ann Clin Lab Sci 2020-01-00

...BRCA2 testing showed good analytical performance and a short hands-on time. Because of its integrated sample preparation...

Overcoming PARPi resistance: Preclinical and clinical evidence in ovarian cance…

Chiappa(M),Guffanti(F),Bertoni(F),Colombo(I)… Drug Resist Updat 2021-00-00

...BRCA2 genes. Inhibition of the poly-ADP-ribose polymerase (PARP) is synthetic lethal with HR deficiency and the use of P...

An updated review of epidemiology, risk factors, and management of male breast …

Khan(NAJ),Tirona(M) Med Oncol 2021-03-15

...BRCA2 and BRCA1 mutation are some of the known risk factors for MBC. Routine screening mammography is not recommended fo...

Identification of pathogenic variants in cancer genes using base editing screen…

Huang(C),Li(G),Wu(J),Liang(J),Wang(X) Genome Biol 2021-00-10

...BRCA2 genes. Our efficiency-corrected scoring model identifies 910 loss-of-function variants for BRCA1/2, including 151 ...

Framing Ethical Concerns and Attitudes towards Human Gene Patents in the Chines…

Du(L),Lin(S),Kamenova(K) Asian Bioeth Rev 2020-09-00

...BRCA2 genes. Overall, the newspapers were uncritical of the Chinese gene patenting regime. News reporting on the issue w...

Mainstream genetic testing for breast cancer patients: early experiences from t…

Beard(C),Monohan(K),Cicciarelli(L),James(PA) Eur J Hum Genet 2021-00-00

...BRCA2 has continued to increase with the lowering costs of testing, raised awareness in the general public, and implicat...

Genome-wide association meta-analysis identifies pleiotropic risk loci for aero…

Lesseur(C),Ferreiro-Iglesias(A),McKay(JD),Bo… PLoS Genet 2021-00-00

...BRCA2). Gene-based association and gene set enrichment identified a set of 48 SqCC-related genes rel to DNA damage and e...

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