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Mutation analysis of the ATR gene in breast and ovarian cancer families.

Heikkinen(Katri),Mansikka(Virpi),Karppinen(S… Breast Cancer Res 2006-01-25

...BRCA2, ATM, TP53, CHK2 and PTEN account for only 20-30% of the familial aggregation of breast cancer, which suggests the...

Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of…

Haffty(B G),Silber(A),Matloff(E),Chung(J),La… J Med Genet 2006-08-11

To evaluate the frequency and distribution of BRCA1 and BRCA2 mutations in a cohort of young women with breast cancer an...

Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG …

Antoniou(A C),Pharoah(P D P),Narod(S),Risch(… J Med Genet 2006-05-18

...BRCA2 mutations were similar to the corresponding estimates based on all BRCA1 or BRCA2 mutations in the meta-analysis. ...

Targeting the DNA repair defect of BRCA tumours.

Turner(Nicholas),Tutt(Andrew),Ashworth(Alan) Curr Opin Pharmacol 2006-05-24

...BRCA2 function. Both BRCA1 and BRCA2 proteins have been implicated in the repair of double-strand DNA breaks by homologo...

Hemochromatosis gene mutations among Finnish male breast and prostate cancer pa…

Syrjäkoski(Kirsi),Fredriksson(Henna),Ikonen(… Int J Cancer 2006-01-11

...BRCA2 mutation 9346(-2)A-->G compared with the rest of the MBC cases, indicating that HFE may be an MBC risk modifier ge...

Common variation in EMSY and risk of breast and ovarian cancer: a case-control …

Benusiglio(Patrick R),Lesueur(Fabienne),Lucc… BMC Cancer 2006-02-27

...BRCA2 exon 3.,We used a genetic association study design to determine if common genetic variation (frequency > or = 5%) ...

Hypoxia down-regulates DNA double strand break repair gene expression in prosta…

Meng(Alice X),Jalali(Farid),Cuddihy(Andrew),… Radiother Oncol 2006-01-24

...BRCA2) in both normal and malignant cultures. Similar decreases in RNA pertaining to the NHEJ-related genes (e.g. Ku70, ...

High incidence of skewed X chromosome inactivation in young patients with famil…

Kristiansen(M),Knudsen(G P S),Maguire(P),Mar… J Med Genet 2006-07-17

...BRCA2 breast cancer (n = 272), BRCA1/BRCA2 germline mutations (n = 35), and sporadic breast cancer (n = 292).,X inactiva...

Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 m…

Lovelock(P K),Healey(S),Au(W),Sum(E Y M),Tes… J Med Genet 2006-12-15

...BRCA2.

BRCA1-2 mutations in breast cancer: identification of nine new variants of BRCA…

Salazar(Raquel),Cruz-Hernandez(Juan Jesús),S… Cancer Lett 2006-04-28

...BRCA2 [2604C>A (Y792X), 8873del4], three missense mutations in BRCA2 [677A>G (H150R), 958G>A (D224N) and 3398A>G (K1057R...

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