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The cancer-risk variant frequency among Polish population reported by the first…

Mroczek(M),Liu(J),Sypniewski(M),Pieńkowski(T… Front Oncol 2023-00-00

...BRCA2 pathogenic/likely pathogenic according to ClinVar allele frequency in the unselected population of 1076 Poles was ...

[Pancreatic cancer screening in a clinical practice setting: it is the moment o…

Adán-Merino(L),Mora-Soler(A),Zaera-De la Fue… Rev Gastroenterol Peru 2022-00-00

...BRCA2 mutation was more frequent in patients with significant lesions (66.7% vs 30%, p=0.376) but smoking and diabetes w...

Detection of inherited mutations for hereditary cancer using target enrichment …

Guan(Yanfang),Hu(Hong),Peng(Yin),Gong(Yuhua)… Fam Cancer 2015-12-30

...BRCA2 in two breast cancer specimens, all confirmed by Sanger sequencing. Accuracy in detecting copy number variation (C...

Pathologic Findings at Risk Reducing Surgery in BRCA and Non-BRCA Mutation Carr…

Cassani(C),Rossi(C),Camnasio(CA),Urtis(M),Fi… Diagnostics (Basel) 2022-12-06

...BRCA2, 11 CHEK2, 7 PALB2, 4 ATM, 1 ERCC5, 1 RAD51C, 1 CDH1, 1 MEN1, 1 MLH1 gene mutation carriers and 15 patients with n...

The RAD51 135G>C polymorphism is related to the effect of adjuvant therapy in e…

Söderlund Leifler(K),Asklid(A),Fornander(T),… J Cancer Res Clin Oncol 2015-06-22

...BRCA2 carriers. In this study, it was investigated whether this polymorphism is related to prognosis of breast cancer an...

Characterizing cyclin-dependent kinase 12(CDK12)-altered aggressive prostate ca…

Iwasawa(T),Kosaka(T),Yasumizu(Y),Hongo(H),Ya… Int J Clin Oncol 2022-12-00

...BRCA2/RB1 co-loss, and the other two had whole genome duplication. Five patients had a long-term survival of  > 6 years,...

Human breast cancer cell death induced by BnSP-6, a Lys-49 PLA₂ homologue from …

Azevedo(Fernanda Van Petten Vasconcelos),Lop… Int J Biol Macromol 2016-10-13

...BRCA2 and TP53 tumor suppressors. Finally, BnSP-6 induced down-regulation of Angiopoetin 1 gene (potent pro-angiogenic f...

Copy number alteration features in pan-cancer homologous recombination deficien…

Yao(H),Li(H),Wang(J),Wu(T),Ning(W),Diao(K),W… Commun Biol 2023-00-16

...BRCA2, PALB2, RAD51C, RAD51D, and BARD1 as the major genetic basis for human HRD, and may also be applied to effectively...

Moreton Lecture: Imaging in the Age of Precision Medicine.

Thrall(James H) J Am Coll Radiol 2016-07-11

...BRCA2 genes. Imaging is poised to play major roles in the age of precision medicine. The imaging community needs to lear...

Hsp90: A New Player in DNA Repair?

Pennisi(Rosa),Ascenzi(Paolo),di Masi(Alessan… Biomolecules 2016-07-13

...BRCA2, CHK1, DNA-PKcs, FANCA, and the MRE11/RAD50/NBN complex, have been described to be client proteins of Hsp90, which...

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