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Addressing health disparities in Hispanic breast cancer: accurate and inexpen...

Dean(Michael),Boland(Joseph),Yeager(Meredi... Gigascience 2016-07-25

Germline mutations in the BRCA1 and BRCA2 genes account for 20-25 % of inherited breast cancers and about 10 % of all br...

Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome.

Hagelstrom(Robert Tanner),Ford(James),Reis... Pediatr Blood Cancer 2016-06-13

...BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and t...

Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Ge...

Shaposhnikov(Mikhail),Proshkina(Ekaterina)... Sci Rep 2016-08-19

...BRCA2, XRCC3, KU80 and WRNexo). The overexpression of different DNA repair genes led to both positive and negative effec...

Comprehensive genomic profiling of extrahepatic cholangiocarcinoma reveals a ...

Lee(Hwajeong),Wang(Kai),Johnson(Adrienne),... J Clin Pathol 2016-09-09

...BRCA2, CDK4, CDK6, FGFR1, FGFR3, PTCH1, RAF1 and STK11 were each altered in a single patient. No IDH1/2 mutations or FGF...

Triple-Negative versus Non-Triple-Negative Breast Cancers in High-Risk Women:...

Podo(Franca),Santoro(Filippo),Di Leo(Giova... Clin Cancer Res 2016-11-03

...BRCA2 (21%), 15 SFH (34%). Magnetic resonance imaging (MRI) sensitivity (90%) outperformed that of mammography (43%, P <...

Hsp90: A New Player in DNA Repair?

Pennisi(Rosa),Ascenzi(Paolo),di Masi(Aless... Biomolecules 2016-07-13

...BRCA2, CHK1, DNA-PKcs, FANCA, and the MRE11/RAD50/NBN complex, have been described to be client proteins of Hsp90, which...

A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated w...

Byrd(Philip J),Stewart(Grant S),Smith(Anna... PLoS Genet 2016-08-03

...BRCA2, previously unreported in FA-N patients. There was also a large increased chromosomal radiosensitivity following i...

The genetic prediction of risk for gynecologic cancers.

Randall(Leslie M),Pothuri(Bhavana) Gynecol Oncol 2016-08-16

...BRCA2, and DNA mismatch repair genes: MLH1, MSH2, MSH6, and PMS2 are important causal agents in hereditary breast and ov...

Genomic Biomarkers for Breast Cancer Risk.

Walsh(Michael F),Nathanson(Katherine L),Co... Adv Exp Med Biol 2016-08-10

...BRCA2, moderately penetrant mutations of genes such as CHEK2, as well as more common genomic variants, including single ...

Decreased Expression of BRCA2 Accelerates Sporadic Breast Cancer Progression.

Saha(Soumi),Mandal(Pranab),Ganguly(Suvro),... Indian J Surg Oncol 2016-04-12

...BRCA2 expression. In patients with higher grade of tumors the level of BRCA2 expression was found to be low. Decreased e...

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