...BRCA2-deficient HGSOC. Our data suggest that PLK1 inhibition restores sensitivity to PARPi in HGSOC with KRAS amplificat...
...BRCA2: 39). The detection rate in BRCA-negative women was 21.8%; the most commonly affected gene was BRIP1 (5.9%). The n...
...BRCA2 (PALB2) is a pancreatic cancer (PC) susceptibility gene reported in Caucasians. However, limited data are availabl...
...BRCA2 gene have a specifically increased lifetime risk of developing breast and tubo-ovarian cancer. Moreover, they are ...
...BRCA2 (BRCAm) evidently demonstrate superior responses when compared to aberrations in other homologous recombination re...
...BRCA2) function, all potentially suppressing malignant tumor development. Our findings might facilitate future therapeut...
...BRCA2, p53, HER1, HER2, cMyc, BCL2, MCL1, CCND1, WNT3A, MAPK1, MAPK3, DAPK1, Casp8, and Casp9 were determined in MCF7 an...
...BRCA2 genes. Women with BRCA mutations are at a significantly increased lifetime risk of developing OC, often presenting...
...BRCA2, 13% for GATA3, 7% for BRCA1, and 3% for PTEN in the same patient cohort. We also found an average 23% HR copy num...
...BRCA2 mutations, 6q loss, and 14q acquisition during tumor progression, but no other significant findings associated wit...
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