Women with BRCA1 or BRCA2 mutation are often advised to undergo preventive oophorectomy. The effectiveness of this inter...
...BRCA2 genes. Low expression of these genes in sporadic tumors extends their significance to sporadic breast and ovarian ...
...BRCA2, both identified about 10 years ago, are responsible for the majority of inherited breast cancer. By virtue of her...
...BRCA2 mutations: a significant difference was obtained compared with controls (6.8% v 2.7%; p<0.001; odds ratio (OR) 2.6...
...BRCA2 genes have been identified in most breast and ovarian cancer families, although other genes may be involved. Natio...
...BRCA2, and Rad51, thereby protecting the genome. Because hypersensitivity to genotoxic stress is a feature of all somati...
...BRCA2. In many laboratories that analyze BRCA1 and BRCA2, previous to direct sequencing, screening techniques to identif...
...BRCA2: 25 families carried a mutation in BRCA2 (BRCA2+; 64.1%) compared with 14 families BRCA1+ (35.9%). The highest inc...
...BRCA2-associated breast cancer.,The incidences of contralateral breast cancer, ipsilateral recurrence, distant disease-f...
...BRCA2. Similar to BRCA1 mice, RAD51-/- mice are embryonic lethal. The RAD51 gene region has been shown to exhibit loss o...
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