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Molecular pathogenesis of Fanconi anemia: recent progress.

Taniguchi(Toshiyasu),D'Andrea(Alan D) Blood 2006-06-29

...BRCA2), appear to cooperate in a pathway leading to the recognition and repair of damaged DNA. Molecular interactions am...

Mitotic defects in XRCC3 variants T241M and D213N and their relation to cancer …

Lindh(Anna Renglin),Rafii(Saeed),Schultz(Nik… Hum Mol Genet 2006-09-19

...BRCA2 proteins. However, in contrast to mutations in BRCA1 and BRCA2, the XRCC3(T241M) protein is proficient in homologo...

Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab …

Mann(Graham J),Thorne(Heather),Balleine(Rose… Breast Cancer Res 2006-03-21

...BRCA2 mutation positive families, but this was less evident in families in which no pathogenic BRCA1 or BRCA2 mutation h...

Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation car…

Domchek(Susan M),Friebel(Tara M),Neuhausen(S… Lancet Oncol 2006-03-28

...BRCA2 mutations. However, the reduction in mortality after this surgery is unclear. We aimed to assess whether BPSO impr...

The RecA binding locus of RecBCD is a general domain for recruitment of DNA str…

Spies(Maria),Kowalczykowski(Stephen C) Mol Cell 2006-04-28

...BRCA2 protein, the RecB-domain may be one of several structural domains that interact with and recruit DNA strand exchan...

Recombination mediator and Rad51 targeting activities of a human BRCA2 polypept…

San Filippo(Joseph),Chi(Peter),Sehorn(Michae… J Biol Chem 2006-07-05

...BRCA2 DNA binding domain. The results thus clarify the role of BRCA2 in Rad51-dependent DNA recombination and repair, an...

A haplotype containing the p53 polymorphisms Ins16bp and Arg72Pro modifies canc…

Osorio(A),Martínez-Delgado(B),Pollán(M),Cuad… Hum Mutat 2006-08-02

Germline mutations in the BRCA1 and BRCA2 genes confer a high lifetime risk of developing breast and other cancers; howe...

Interaction between Arabidopsis Brca2 and its partners Rad51, Dmc1, and Dss1.

Dray(Eloïse),Siaud(Nicolas),Dubois(Emeline),… Plant Physiol 2006-05-31

...Brca2 and the two Dss1 isoforms are named AtBrca2(IV), AtBrca2(V), AtDss1(I), and AtDss1(V) after their chromosomal loca...

Population-based study of changing breast cancer risk in Icelandic BRCA2 mutati…

Tryggvadottir(Laufey),Sigvaldason(Helgi),Ola… J Natl Cancer Inst 2006-01-31

...BRCA2 founder mutation 999del5.,Information on all breast cancers diagnosed in Iceland since 1911 was obtained from the ...

BRCA1 regulates RAD51 function in response to DNA damage and suppresses spontan…

Cousineau(Isabelle),Abaji(Christine),Belmaaz… Cancer Res 2006-02-23

The breast/ovarian cancer susceptibility proteins BRCA1 and BRCA2 maintain genome stability, at least in part, through a...

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