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Molecular Docking of Bioactive Compounds Against BRCA and COX Proteins.

Prog Drug Res 2016-04-08

...BRCA2 genes and COX proteins is carefully texted in this chapter to check docking of the best inhibitor molecule.

BRCA2 regulates DMC1-mediated recombination through the BRC repeats.

Martinez(Juan S),von Nicolai(Catharina),Ki... Proc Natl Acad Sci U S A 2016-08-29

...BRCA2. Here we report that human DMC1 interacts directly with each of the BRC repeats of BRCA2, albeit most tightly with...

Polymorphism rs144848 in BRCA2 may reduce lung cancer risk in women: a case-c...

Lin(Yong),He(Fei),Zhang(Xin),Yu(Tingting),... Tumori 2016-09-02

...BRCA2 is important in DNA repair, few data are available on the association between BRCA2 polymorphisms and lung cancer ...

Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-...

Kang(Xiaozheng),Liu(Hongliang),Onaitis(Mar... Carcinogenesis 2016-08-10

...BRCA2). After combined the results from TRICL with those from Harvard and deCODE, the most significant association (P co...

Multiplexed pancreatic genome engineering and cancer induction by transfectio...

Maresch(Roman),Mueller(Sebastian),Veltkamp... Nat Commun 2016-07-12

...Brca2-inactivation in a Kras-mutant context. We also demonstrate modelling of chromosomal deletions and targeted somatic...

Clinical characteristics and genetic subtypes of Fanconi anemia in Saudi pati...

Ghazwani(Yahya),AlBalwi(Mohammed),Al-Abdul... Cancer Genet 2016-09-22

...BRCA2 mutation c.7007G > A (p.Arg2336His) and one had a novel c.3425del (p.Leu1142Tyrfs*21) PALB2 mutation. Another infa...

Gene and pathway level analyses of germline DNA-repair gene variants and pr...

Saunders(Edward J),Dadaev(Tokhir),Leongamo... Br J Cancer 2016-08-24

...BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility va...

Effect of BRCA2 mutation on familial breast cancer survival: A systematic rev...

Shao(Jun),Yang(Jie),Wang(Jun-nai),Qiao(Lon... J Huazhong Univ Sci Technol... 2016-09-15

...BRCA2 mutation carriers and patients with sporadic disease. Our results suggest that BRCA2 mutation increases long-term ...

Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response.

Zhang(Feng),Shi(Jiazhong),Bian(Chunjing),Y... Cell Rep 2016-09-20

...BRCA2 disrupt the interaction with PAR and abolish the fast relocation of BRCA2 to DNA lesions. The quickly recruited BR...

BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PA...

Zhen(David B),Rabe(Kari G),Gallinger(Steve... Genet Med 2016-05-27

...BRCA2 (including analysis of deletions and rearrangements), PALB2, and CDKN2A. We compared prevalence of deleterious mut...

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